Cancer has no borders. Neither do we.
年度報告2023
?2023
2 4 8 51 141 142 169 178 237 268 273 368 373
?2023
Olivier Brandicourt
Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. Hooper
Ranjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders
Anthony C. Hooper
Olivier Brandicourt
Corazon (Corsee) D. Sanders
Margaret Han DuganRanjeev Krishana
Donald W. GlazerMichael GollerAnthony C. HooperAlessandro Riva
Alessandro RivaMargaret Han DuganMichael GollerCorazon (Corsee) D. Sanders
Anthony C. HooperOlivier Brandicourt
Margaret Han DuganRanjeev KrishanaCorazon (Corsee) D. Sanders
* 2024122Thomas MalleyMalley
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20192020202120222023
620,7751,390,0054,382,8873,875,0373,185,984364,7283,268,7252,241,962665,2512,600862,3843,885,4916,014,3253,738,5502,393,3011,612,2895,534,7958,535,5256,379,2905,805,275633,9341,731,5142,402,9621,995,9352,267,94816,150––––978,3553,803,2816,132,5634,383,3553,537,327
(1) 10-K
?2023
(U.S. GAAP)
(U.S. GAAP)GAAP
GAAPGAAPGAAPGAAP
GAAPGAAPGAAPGAAPGAAP
GAAP
GAAPGAAPGAAPGAAPGAAP
GAAP
2023
?
2023? 20232573.7%?
?
202313
128.5%
?2023
? sonrotoclaxCLL
3BTK CDACR/R CLLR/R MCL?
2024314(FDA)
?
PD-(L)1(ESCC)20231222FDA
??(R/R)(CLL)3ALPINE(PFS)20231121(IND)
2(CDK2)20231117(EC)
?R/R(FL)20243,500(BD)
?2023
1. 3,000
(CRO)75%
2. 1,100
???
(R/R)(CLL)(PFS)(ORR)BCL-2sonrotoclaxBTK(CDAC)BGB-16673
KRASPRMT5CDK4CDK2B7H3-ADCCEA-ADCB7H4-ADCMUC1×CD16AClaudin6×
CD3CDACADCmRNA3.
???
29375,000
800ALPINE?
BTK2022(ASH)
?202312(FDA)??
R/R CLL3ALPINE
?2023
(PFS)
?2023?
2022128.5%
?sonrotoclaxBCL2BTK-CDACCLL
BPD-1
?
PD-1/PD-L1
?
20247ESCC
?
KRASPRMT5CDK4CDK2B7H3-ADCCEA– ADCB7H4-ADCMUC1×CD16AClaudin6× CD3
4. 3,700500
?2023CLL(SLL)
?
??
BTKPD-1/PD-L1
?
2023
??
(EMA)
5. 20231231
32222024
?2023
202320221231
202320221231
123120232022%
2,189,8521,254,612935,24074.5% 268,927161,309107,61866.7%
2,458,7791,415,9211,042,85873.7%
379,920286,47593,44532.6%2,078,8591,129,446949,41384.1% 1,778,5941,640,508138,0868.4% 1,504,5011,277,852226,64917.7% 3,5007512,749366.0%
3,286,5952,919,111367,48412.6%(1,207,736)(1,789,665)581,929(32.5)% 74,00952,48021,52941.0% 307,891(223,852)531,743(237.5)%
(825,836)(1,961,037)1,135,201(57.9)%
55,87242,77813,09430.6%(881,708)(2,003,815)1,122,107(56.0)%
?2023
20221231142023123110
???202320221231
123120232022%2,189,8521,254,612935,24074.5% 71,980–71,980 79,43146,82232,60969.6% 104,477104,994(517)(0.5)% 13,0399,4933,54637.4%
268,927161,309107,61866.7%2,458,7791,415,9211,042,85873.7%
?2023
12312023%2022%1,128,21945.9%502,62635.5%945,55138.5%389,71027.5%182,6687.4%112,9168.0%1,101,95144.8%840,03259.3%1,093,09144.5%840,03259.3%8,8600.3%––%202,0148.2%63,2574.5%122,2285.0%14,8641.0%79,7863.2%48,3933.5%26,5951.1%10,0060.7%28,9821.2%10,0060.7%(2,387)(0.1)%––%2,458,779100.0%1,415,921100.0%
123120232022%
?
1,290,396564,651725,745128.5%?
536,620422,885113,73526.9%?
76,01879,049(3,031)(3.8)%?
92,82863,39829,43046.4%
?
56,54738,12418,42348.3%
?
54,34236,10718,23550.5%
?
13,96015,213(1,253)(8.2)%
?
39,79913,69626,103190.6%
?
6,6685,4601,20822.1%
22,67416,0296,64541.5%2,189,8521,254,612935,24074.5%
?2023
202312312213
??20231231
?
13128.5%202312
?
9.4563.897142.6%?
CLLSLL202312
?
1.93828.9%
20231231
?
1.2222,880
722.3%194.8%CLLSLLWM20231231
?
5.36626.9%202312
?
?
20231,3202023320241202312312.6892023
202312317,940
1.0457,200
1,30020221231
1.61320221231
4,6801.05
950320241231
202212312.865202312313.799??
?2023
202312311882.7%202212311077.2%
20221231161.3818.4%2023123118202320221231
123120232022%
551,417469,49781,92017.4% 46,80068,665(21,865)(31.8)%
53,31598,955(45,640)(46.1)%651,532637,11714,4152.3%1,127,0621,003,391123,67112.3%1,778,5941,640,508138,0868.4%
1,558,9601,474,91984,0415.7%
1. 202312311.0865,330
5,5302.
GAAPGAAP
?2023
20231231
?Sonrotoclax(BGB-11417)
?
20221231101.23712.3%11
123120232022%1,504,5011,277,852226,64917.7%
1,284,6891,077,977206,71219.2%1.
GAAPGAAP20221231132.26617.7%2023123115
202212315,2502,15041.0%202312317,400
?2023
202312313.079BMS
3.629
202212312.239
202312315,590202212314,280
20231231
202112BEPS
?2023
GAAP
123120232022GAAPGAAP379,920286,475
8,578–3,7393,225367,603283,250GAAPGAAP1,778,5941,640,508
163,550139,348
56,08426,2411,558,9601,474,919GAAPGAAP1,504,5011,277,852
204,038163,814
15,77436,0611,284,6891,077,977GAAPGAAP3,286,5952,919,111
367,588303,162
71,85862,302
3,5007512,843,6492,552,896GAAPGAAP(1,207,736)(1,789,665)
367,588303,162
80,43662,302
7,2393,976(752,473)(1,420,225)
?2023
20231231(i)13(ii)13018(iii)
69.7
20221231173.2106.8%20231231358.0
20221231282.347.4%20231231416.1
20221231216.612.4%20231231
243.4(i)(ii)
20221231845.956.5%202312311,324.2
202320221231315.1294.8
?2023
1231202320223302,310290,284368,2052,570614,5511,379145548
315,111294,781
202320221231
123120232022217,803184,775162,969139,16887,57251,80630,08318,815139,93641,81755,36830,971693,731467,35220221231467.448.4%20231231
693.7(i)(ii)(iii)
202212315.381202312318.860
64.6%
?2023
20231231
1231202320223,185,9843,875,0372,600665,251885,984538,1172023202212319202023123180201792023123112
20231231(BeiGene,Ltd.)8.860(BeiGene, Ltd.)
5.47212
20211215PRC
192.60391.68115,055,26034217
2023123112
?2023
202320221231
1231202320223,875,0374,382,887(1,157,453)(1,496,619)60,0041,077,123416,478(18,971)(8,082)(69,383)(689,053)(507,850)3,185,9843,875,037
20231231128.817
3.7059,480
BMS
202212311520
2.239
3.7481.324
?2023
202312316,0006.732
5.6191,5001,9401,490
202212311116
3.2541.4371,590150
202312314.1656.615
5,5702,2503.0961,37020246.884202212311,9004.171
3.138
4,7003,740
?2023
20231231
49,15623,49925,657169,212140,77528,437885,984688,366197,61832,1018,93923,162483,651137,809345,8428,9052,2136,69214,9953,57711,418333,498333,498–1,977,5021,338,676638,826
?2023
202312311.6924,120BMS1.280BMS
6.8841.976
20231231
12.5
20231231
4.837
?2023
1,51020231231
20231231
202312313.335
7,520202242920231231
5.024
?
2023
NRDL
?2023
202312311.0
?2023
202320221231
20232022123132391,4205502607
?2023
1002023123110
202312315.74120231231100570
2023202212313.5801.732
1994PBOC
?2023
20052023202212312.8%8.2%
20231231
202312312022123112.3%25.0%
?2023
7,520202242920231231
5.024
20231231
20231231
20231231
2023123110,500202212319,000
2023123116202214
?2023
2023123114.2202212315.5
200.4202212
31123.9
2023123120221231
20231231
?2023
2024417
Olivier Brandicourt68Margaret Han Dugan67Donald W. Glazer79Michael Goller49Anthony C. Hooper69Ranjeev Krishana50Alessandro Riva63Corazon (Corsee) D. Sanders67
5620101020052009BioDuro, LLCPharmaceutical ProductDevelopment Inc.20022004Galenea Corp.
19982002Telephia, Inc.2007(The Nielsen Company)19971998Genta Inc.
(McKinsey & Company)1990619961
?2023
61201622011
20032010202019972010Howard Hughes Medical Institute20012010
George L. MacGregor2004JoyantPharmaceuticals, Inc.219719847
1991520042013
?
2023
Olivier Brandicourt6820241Brandicourt201911Blackstone Life SciencesBlackstone GroupBrandicourtAlnylam Pharmaceuticals, Inc.RNAi
BenevolentAI S.A.Dewpoint Therapeutics, Inc.AvenCell Therapeutics, Inc.
CAR-TBrandicourt30
2015420198Sanofi S.A.Sanofi20131120153Bayer HealthCare AG20002013Pfizer Inc.
SanofiBrandicourt201920172019BrandicourtBrandicourtBrandicourt
Margaret Han Dugan67202221DuganSchrodinger,Inc.SDGRDracen Pharmaceuticals, Inc.
2018Dracen20DuganAmerican CyanamidDuganDugan
?2023
Donald W. Glazer79201322000GlazerGMOTrust2005GMO TrustGlazerProvant,Inc.200220101992
1995GlazerMugar/Glazer Holdings19921993
WHDH-TV, Inc. 1997GlazerGoodwin Procter LLP19701978Ropes & Gray LLP19781992Ropes & Gray19781991
Provant, Inc.GlazerEnvironics Inc.Kronos IncorporatedReflective Technologies, Inc. Teleco Oilfield Services Inc.Glazer1966619696
19705GlazerGlazer and FitzGibbon on Legal Opinions
Massachusetts Corporation Law& PracticeGlazerMichael Goller4920154GollerBaker Brothers Investments2005Baker BrothersGoller19992003JPMorgan Partners,LLC19971999Goller(MerrillLynch and Co.)GollerDBV Technologies SA
20172019Levo Therapeutics, Inc.Goller1997520055
GollerAnthony C. Hooper6920201Hooper20201201892020120112018820102011HooperBristol Myers Squibb Company(BMS)20092010HooperBMS20042009HooperBMSHooperBMS
BMSHooperHooper19781988MBAHooperMannKind CorporationMNKDHooperHooper
?2023
Ranjeev Krishana5020141020202Krishana2011Baker Bros. Advisors LPBaker Bros.Krishana(Pfizer, Inc.)
Krishana200320072008201120082010KrishanaKrishanaAccenture plcKrishana19955
20016Krishana
Alessandro Riva6320222120212023RivaIntima Bioscience, Inc.20192021Ichnos Sciences
20172019Riva
Kite Pharma20052016Riva
GSKRivaCentury Therapeutics, Inc.
iPSCNKTRivaTransgene SATNGTNG
Farmitalia Carlo ErbaRh?ne-Poulenc RorerAventis(BCIRG)(CIRG)RivaRiva
?2023
Corazon (Corsee) D. Sanders6720208Sanders(Bristol Myers Squibb Corporation)201911
20202Sanders201832019112017120183Juno Therapeutics
19942017SandersGenentechGenentech(Late StagePortfolio Committee)Genentech(Late Stage Clinical Operations)GenentechGenentechGenentech DATA
Sanders(Fred Hutchinson CancerResearch Center)(Board of Trustees)Molecular Templates Inc.MTEMLegend Biotech CorporationLEGNAltruBio Inc.AbGenomicsUltragenyx Pharmaceutical Inc.RARESanders(Magna Cum Laude)Sanders
522014106618(Hillhouse Capital)2005
1995720035
?2023
2024417
Chan Lee56
6220184202141
251720184200920184201720184(Pfizer Essential Health)2004200920012004
199220082018(RDPAC)20152018
(NDPE)2017201720171993419901
?2023
532021620206
20182020(AlexionPharmaceuticals)50
20152018(Quest Diagnostics)
20072012Johnson &Johnson (J&J)(Xian-Janssen)(PepsiCo)1999(Duke University)(Fuqua School of Business)1992
472021420115
2010Joyant Pharmaceuticals19962001Chan Lee5620227Lee2520162022Lee
20082016LeeLeeLee
?2023
13.51(B)(1)
20231231
13.51(B)(1)
Anthony C. Hooper2023417
20239
Thomas Malley2023913
2024122Olivier Brandicourt20241232024
?2023
20231231
2010102820188806160201623BGNE20211215688235
EUSA Pharma
180183
20231231
?2023
20231231276
2023123161.3%
16.0%20231231
2022123120221231
69.0%18.1%20232022123126.4%23.9%
2023202212318.0%12.0%202312315%
?2023
20231231
Thomas Malley2024122Thomas Malley
2024123Olivier BrandicourtThomas MalleyOlivier Brandicourt20241232024319Olivier Brandicourt20241232024321
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?2023
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?2023
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?2023
?
?
? 10-K?
202012
174.8515,895,001206,635,013
20.5%2,779,241,000(a)201910303036%(b)
1.007.8420191031
26%(c)2019103126%
?2023
2019112920231231
(%)
20221231
20231231
20231231
(a)
2,779,241100.00%2,080,0682,229,632549,609(a) 12.5
20191129
2026
201911120191292020132020924
20.6%
20.4%
75,000,000
?2023
2020121(a)20%(b)60(c)
20203182020925202010
20219165,5292,151,87750,000,0002022123150,000,000
2021121520216162021
192.60
234.89391.68115,055,260
3,392,616,000
(i)(ii)(iii)(iv)(v)20231110
?2023
202011162021129202142020215142021612021621202162820216302021792021728202110152021111620211123202111242021112920211130202112220211262021127202112132021122120211228202242920226272022830202292820234252023829202311132021430
2023123113780
20231231
20221231
20231231
20231231
13,245,9404,499,8497,169,4706,076,470
467,700376,601434,18833,512150,000153,451153,451(3,451)*136,36071,580110,24026,1206,000,0002,662,6744,832,2811,167,7191,630,155489,000978,000652,15521,630,1558,253,15513,677,6307,952,525
*
?2023
2023123120231231279
2929
202312319
20231231886.02022538.1
?
2023
202312315.420226.8
20231231
2020317
2020924
20.6%20219
165,5292,151,87750
20231231
?2023
20231231
Olivier Brandicourt
Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. Hooper
Ranjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders
(1) 2024123Olivier Brandicourt
(2) Anthony C. Hooper20234172023416
Anthony C. Hooper* 2024122Thomas MalleyMalley
Malley
Malley
?2023
2026202420252024Donald W. GlazerMichael GollerOlivier BrandicourtCorazon (Corsee) D. SandersOlivier Brandicourt
20241Olivier Brandicourt2024Olivier Brandicourt
2027Olivier Brandicourt(i)20241123.09D(ii)
202312313.13
?2023
2024319
65,0002023
20,00020232,00010,0002023
1,0002024412023
65,00035,00017,50030,00015,00020,000
(1)10,000
(2)20,00010,00020,00010,000
(1) 20232,000
(2) 20231,000
?
2023
400,000
400,000202150%50%
(i)100%(ii)
100%
(i)(ii)
20162016
1,000,00020192
202220231231
20.621.2
242526
?2023
20174251,100,000
100%
(i)(ii)(iii)
(iv)(i)(ii)12(iii)(iv)20,000(v)
20201224
?2023
2010201872420212242023127202411202612312024
100,000202420241120261231
302024
2024
20231231
20231231
?2023
20231231
20231231
20231231
8.10
?2023
20231231XV
(a)XV78
(b)352(c)
(1)26,821,201
(2)
1.98%
9,545,000
(3)
0.70%
102,188
(4)
0.01%
7,727,927
(5)
0.57%
28,984,115
(6)
2.14%
510,941
(7)
0.04%
481,533
(8)
0.04%
1,387,802
(9)
0.10%
15,127,403
(10)
1.12%
4,058,998
(11)
0.30%
1,127,542
(12)
0.08%
(13)
0.000004%
Margaret Han Dugan113,815
(14)
0.01%
Donald W. Glazer3,190,679
(15)
0.24%
Michael Goller453,232
(16)
0.03%
Anthony C. Hooper183,885
(17)
0.01%
Ranjeev Krishana453,232
(18)
0.03%
Thomas Malley1,365,980
(19)
0.10%
Alessandro Riva113,815
(20)
0.01%
Corazon (Corsee) D. Sanders136,500
(21)
0.01%
436,150
(22)
0.03%
?
2023
(1) 202312311,354,719,193
4,794,031
(2) (1)1,292,260(2)24,849,647
(3)679,294
(3) Roth IRA PENSCO
(4) The John Oyler Legacy Trust
(5)
(6) Oyler Investment LLC
Oyler Investment LLC 99%
(7) The Oyler Family Legacy Trust
(8)(9)
(10) (1)5,291,082(2)9,667,965
(3)168,356
(11) Wang Investment LLCWang Investment LLC99%(12)
?2023
(13)
(14) (1) Dugan16,692(2)DuganDugan84,201(3) Dugan12,922
(15) (1) Glazer2,754,529(2)GlazerGlazer406,536(3) Glazer29,614
(16) (1) Goller33,774(2)GollerGoller
406,536(3) Goller37,414
(17) (1) Hooper7,800(2)HooperHooper
146,471(3) Hooper29,614
(18) (1) Krishana33,774(2)KrishanaKrishana
406,536(3) Krishana12,922
(19) (1) Malley423,774(2)MalleyMalley929,284(3) Malley12,922
(20) (1) Riva16,692(2)RivaRiva84,201
(3) Riva12,922
(21) (1) Sanders16,978(2)SandersSanders106,600(3) Sanders12,922
(22) (1)16,692(2)406,536
(3)12,92220231231
(a)XV7
(b)352(c)
?2023
20231231
XV23
(1)Amgen Inc.246,269,42618.18%Julian C. Baker
(2)
138,757,83110.24%Felix J. Baker
(2)
138,757,83110.24%Baker Bros. Advisors (GP) LLC
(2)
138,302,17110.21%Baker Bros. Advisors LP
(2)
138,302,17110.21%HHLR Advisors, Ltd.
(3)
133,587,6559.86%HHLR Fund, L.P.
(3)
129,433,0599.55%Baker Brothers Life Sciences Capital, L.P.
(2)
126,893,3119.37%The Capital Group Companies, Inc.
(4)
106,680,7527.87%JPMorgan Chase & Co.
(5)
13,828,5011.02%10,951,288 (S)0.81% (S)
247,0870.02%638,1750.05%5,8370.0004%
87,817,8996.48%
(S)
(1) 202312311,354,719,193
4,794,031
(2) Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLC
Baker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.
BBAMichael GollerRanjeev Krishana
BBA
?2023
Baker Brothers Life Sciences Capital, L.P.Baker Bros. Advisors (GP) LLCJulian C. BakerFelix J.Baker2023111420231114125,986,847Baker Brothers Life Sciences, L.P.Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBBA667, L.P.11,408,860BakerBrothers Life Sciences, L.P.125,986,847723,996BBABaker Brothers Life Sciences Capital, L.P.
Baker Brothers Life Sciences, L.P.125,986,847723,996BBAJulian C. BakerFelix J. Baker270,868FBB3 LLC144,517
(3) (i) 133,587,655HHLR Fund, L.P.YHG Investment, L.P.(ii) 13,447,603HillhouseBGN Holdings LimitedHHLR Advisors, Ltd.YHG Investment, L.P.HHLR Fund,L.P.Hillhouse Capital Management, Ltd.Hillhouse Fund II, L.P.Hillhouse Fund II, L.P.Hillhouse BGN Holdings LimitedHHLR Advisors, Ltd.
HHLR Fund, L.P.YHG Investment, L.P.133,587,655Hillhouse CapitalManagement, Ltd.Hillhouse BGN Holdings Limited13,447,603Hillhouse Fund II, L.P.Hillhouse BGN Holdings Limited13,447,603
(4) (i) 12,059,093Capital International, Inc.(ii) 902,312Capital International Limited
(iii) 2,536,443Capital International Sarl(iv) 88,023,999Capital Research andManagement Company(v) 207,814Capital Group Investment Management Private Limited
(vi) 2,951,091Capital Group Private Client Services, Inc.Capital Group International, Inc.Capital Research and Management CompanyCapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.Capital Group International,Inc.Capital Bank and Trust CompanyThe Capital Group Companies, Inc.Capital Research and Management CompanyCapital Group International, Inc.CapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.18,656,753Capital Research and Management CompanyThe Capital Group Companies Inc.The Capital Group Companies Inc.Capital Research and Management Company
106,680,752
(5) JPMorgan Chase & Co.20231120
JPMorgan Chase & Co.102,537,49910,951,288
87,817,8991,678,578998,355
20231231
XV23
?2023
201120162018202262220162018
2023111720231120242016201817
44,391,919
3.28%202381202422920182024229
1. 2011
20114152015417201120162220162011
2011
201143,560,4322016222016
201120231120112,643,0422011202311202312311,215,1882023123120244171,427,6861,357,7392024417
0.1%2011
?2023
20112011
2011
2011
0.011.85
2011
20112016222016201120112018730
?2023
2011
2023123120112402011
20115202016131202311202312312011
2023
20231231
201343
(1)
100.01879,267–879,255
(4)
12–2015629
(1)
100.50500,000–––500,000Thomas Malley*2016125
(2)
1.85552,752–––552,752
201343
(3)
100.0112–––12–2015629
(3)
100.5011–––112011520 2016131
(3)
100.01
1.85
663,694–335,933
(5)
–140327,6212011520 2016131
(3)
100.01
1.85
47,306–
–
–447,302
2,643,042–1,215,188–1681,427,686
* Thomas Malley2024122
(1) 20%80%20%48
?2023
(2)
(3) 20%/25%80%/75%20%/25%48/36
(4) 1317.81
(5) 1313.5520.25
0.011.85
(6) Thomas Malley2024122Thomas Malley20241232024122
2. 2016
20181172018127201620161142016
2016202041320206172016201657,200,0002016203020224172022622
2016201666,300,000201618
2016
2016
?
2023
20162022622
10%2016
30%202311201675,034,50420231120231231
44,391,919201620231231202441737,575,47237,217,0232016
2023112016189,114,82120162023112023123123,621,741202312312024417165,493,255162,887,4752024417
11.99%2016
2016
1%
?2023
(i)
1/13(ii)
201620162016203041320166
20162023123120161,1452016
201628202312292016
0.528.81
?2023
20231158,683,14420162023123161,516,7602016
(1)(2)
2023
20231231
2016 1116(3)
102.792.842,047,500––––2,047,5002017 927(3)
106.737.70935,000––––935,0002018 430(3)
1013.3713.04996,810––––996,8102018 626(3)
1012.7012.341,310,088––––1,310,0882019 65
(3)
109.259.232,193,282––––2,193,2822020 617(3)
1013.3313.421,821,976––––1,821,9762021 616(3)
1025.5426.53906,906–––906,9062022 622(3)
1011.7411.981,887,678––––1,887,6782023 615(3)
1016.0116.41–1,349,907–––1,349,9072016 1116(3)
102.792.841,613,430––––1,613,4302017 927
(3)
106.737.70750,000––––750,0002018 626
(3)
1012.7012.34655,044––––655,0442019 65
(3)
109.259.23747,708––––747,7082020 617
(3)
1013.3313.42560,599––––560,5992021 616
(3)
1025.5426.53241,839––––241,839
?2023
(1)(2)
2023
202312312022 622
(3)
1011.7411.98471,913––––471,9132023 615
(3)
1016.0116.41–327,249–––327,249Anthony C. Hooper*2020
(5)
1012.6212.2221,970––––21,9702020 617
(5)
1013.3313.4245,383––––45,3832021 616(5)
1025.5426.5317,498––––17,4982022 622(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.4126,975–––26,975Margaret Han Dugan2022
(5)
1016.4716.2222,581––––22,5812022 622
(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.41–26,975–––26,975Donald W. Glazer2017
(4)
102.842.83199,992––––199,9922018 66
(5)
1015.7316.1517,442––––17,4422019 65
(5)
109.259.2364,610––––64,6102020 617
(5)
1013.3313.4245,383––––45,3832021 616
(5)
1025.5425.6317,498––––17,4982022 622
(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
20231231Michael Goller2017
419(4)
102.842.83199,992––––199,9922018 66(5)
1015.7316.1517,442––––17,4422019 65
(5)
109.259.2364,610––––64,6102020 617
(5)
1013.3313.4245,383––––45,3832021 616(5)
1025.5425.6317,498––––17,4982022 622
(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.41–26,975–––26,975Ranjeev Krishana2017
(4)
102.842.83199,992––––199,9922018 66
(5)
1015.7316.1517,442––––17,4422019 65
(5)
109.259.2364,610––––64,6102020 617
(5)
1013.3313.4245,383––––45,3832021 616
(5)
1025.5425.6317,498––––17,4982022 622
(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
20231231Thomas Malley*2017
62(5)
(10)
2.943.15169,988––––169,9882018 66(5)
(10)
15.7316.1517,442––––17,4422019 65(5)
(10)
9.259.2364,610––––64,6102020 617
(5)
(10)
13.3313.4245,383––––45,3832021 616
(5)
(10)
25.5425.6317,498––––17,4982022 622
(5)
(10)
11.7411.9834,645––––34,6452023 615
(5)
(10)
16.0116.41–26,975–––26,975Corazon D. Sanders
2020 824
(5)
1018.5018.2627,482––––27,4822021 616
(5)
1025.5425.6317,498––––17,4982022 622
(5)
1011.7411.9834,645––––34,6452023 615
(5)
1016.0116.41–26,975–––26,975Alessandro Riva
2022 228
(5)
1016.4716.2222,581––––22,5812022 622
(5)
1011.7411.9834,645––––34,6452023 615(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
202312312017 419
(4)
102.842.83199,992––––199,9922018 66
(5)
1015.7316.1517,442––––17,4422019 65(5)
109.259.2364,610––––64,6102020 617
(5)
1013.3313.4245,383––––45,3832021 616
(5)
1025.5425.6317,498––––17,4982022 622(5)
1011.7411.9834,645––––34,6452023 615(5)
1016.0116.41–26,975–––26,975
–
2018 430
(6)
1013.3713.04766,599––––766,5992019 65
(3)
109.259.23797,550––––797,5502020 617
(3)
1013.4213.33756,821––––756,8212021 616
(3)
1025.5425.63483,678––––483,6782022 622
(3)
1011.7411.981,061,814––––1,061,8142023 615
(3)
1016.0116.41–760,851–––760,851
?2023
(1)(2)
2023
202312312020 630(3)
1014.5514.66104,754––––104,7542021 616
(3)
1025.5426.53177,853––––177,8532022 622(3)
1011.7411.98589,888––––589,8882023 615(3)
1016.0116.41–409,058–––409,0582016 713
(3)
102.272.29––––––2017 627(3)
103.503.49––––2018 626
(3)
1012.7012.34364,208––––364,2082019 65
(3)
109.259.23558,285––––558,2852020 617
(3)
1013.3313.42525,564––––525,5642021 616
(3)
1025.5426.53332,527––––332,5272022 622
(3)
1011.7411.98707,876––––707,8762023 615
(3)
1016.0116.41–507,234–––507,234Chan Lee
2022 85
(3)
102.262.27188,929––––188,9292023 615
(3)
1016.0116.41–248,950–––248,950
?
2023
(1)(2)
2023
202312312016713
(3)
102.272.29200,000–––200,0002016713
(3)
102.2716.162.293,046,805–292,500–122,754,2932016722
(3)
102.1319.142.1091,460–22,633––68,8272016722
(6)
102.1317.532.10786,608–54,340–36732,2322016729
(3)
102.112.0214–––113201689
(3)
102.042.10–––––2016822
(3)
102.282.24–––––201692
(3)
102.2619.302.27207,575–207,5714–2016912
(3)
102.332.42–––––2016919
(3)
102.512.38–––––2016926
(3)
102.352.27–––––20161012
(3)
102.482.426–––620161012
(6)
102.482.42–––––20161017
(3)
102.4216.322.5561,399–5,187–56,2122016111
(3)
102.562.57–––––2016117
(3)
102.432.46–––––2016118
(3)
102.462.51–––––20161116
(3)
102.792.84–––––20161121
(3)
102.462.42–––––20161128
(3)
102.492.38–––––
?
2023
(1)(2)
2023
2023123120161130
(3)
102.432.441,274–––1,2742016121
(3)
102.442.37–––––2016129
(3)
102.072.0934,099–––34,099201713
(3)
102.342.397,800–––7,800201715
(3)
102.4414.402.3963,661–63,661––201719
(3)
102.3718.682.43132,496–132,496––2017117
(3)
102.512.53–––––2017117
(6)
102.5117.782.5347,216–11,167–28635,7632017123
(3)
102.462.49–––––2017130
(3)
102.802.62–––––201721
(3)
102.682.77144,989–––144,989201726
(3)
102.762.7632,201–––32,201201728
(3)
102.672.78–––––2017213
(3)
102.7716.652.7740,443–31,200–9,2432017227
(3)
102.972.93–––––201736
(3)
103.143.06–––––2017313
(3)
103.083.02116,701–––116,7012017320
(3)
103.0416.513.0484,968–15,600–69,3682017327
(3)
102.792.79–––––2017331
(6)
102.8117.752.8241,405–12,701–28,704
?2023
(1)(2)
2023
20231231201743
(3)
102.822.82–––––2017410
(3)
102.862.91–––––2017411
(3)
102.912.95–––––2017417
(3)
102.9216.732.9511,427–11,427––2017424
(3)
102.822.89–––––2017426
(3)
103.013.09–––––201751
(3)
103.1420.373.13260,663–260,663––201752
(6)
103.1315.043.12104,689–3,835–100,854201753
(3(3)
103.123.1211,999–––11,999201758
(3)
103.022.98–––––2017510
(3)
102.882.92–––––2017515
(3)
102.8115.702.909,100–9,100––2017530
(3)
102.8815.392.8821,060–21,060––201761
(6)
102.8315.772.941,093,690–945,776–147,9142017612
(3)
102.993.0012,727–––12,7272017614
(3)
103.0417.593.05583,895–176,735–407,1602017615
(6)
103.0517.123.043,144,284–395,902–9362,747,4462017621
(3)
103.3114.103.4517,784–17,784––2017623
(3)
103.413.45–––––
?2023
(1)(2)
2023
202312312017627
(3)
103.5019.743.493,034,478–901,84952,132,6242017629
(3)
103.5014.773.4543,654–9,997–33,6572017710
(3)
105.4016.785.456,760–5,460–1,3002017717
(3)
105.674.19–––––2017717
(6)
105.6718.814.19292,825–58,695–234,1302017724
(3)
105.955.65–––––2017731
(3)
105.5819.455.4299,996–39,000–60,9962017731
(6)
105.5816.825.42336,271–50,752–285,519201781
(3)
105.4218.695.58156,000–117,000–39,000201782
(6)
105.585.45–––––201783
(3)
105.455.5119,994–––19,994201787
(3)
105.5620.355.9597,500–58,500–39,000201788
(3)
105.9514.866.0312,649–12,649––2017810
(3)
105.955.59–––––2017811
(3)
105.595.46–––––2017817
(3)
105.395.32–––––2017825
(3)
105.385.29–––––2017828
(3)
105.295.2824,167–––24,1672017831
(3)
105.305.30–––––
?2023
(1)(2)
2023
202312312017831
(6)
105.3017.585.30180,596–12,428–168,168201795
(3)
105.7820.615.68269,997–234,988–35,0092017912
(3)
105.395.43–––––2017913
(3)
105.435.82–––––2017918
(3)
106.226.3722,269–––22,2692017922
(3)
106.5317.866.5568,588–68,588––2017925
(3)
106.556.56121,992–––121,9922017926
(3)
106.568.71–––––2017929
(3)
107.497.9637,492–––37,4922017111
(3)
107.1016.136.84226,356–27,300–199,05620171130
(3)
106.386.1510,764–––10,764201815
(3)
107.727.5819,071–––19,0712018131
(3)
109.5210.4480,017–––80,0172018228
(3)
1011.6120.9411.047,904–7,904––2018430
(3)
1013.3713.046,149–––6,149201666
(5)
1015.7316.1517,442–––17,4422018626
(3)
1012.7017.7212.34889,369–247,936–641,4332018629
(3)
1011.9011.8312,103–––12,103
?2023
(1)(2)
2023
202312312018831
(3)
1013.6717.9513.6613,741–13,741––2018831
(7)
1013.6718.8913.66108,537–101,829–6,7082018928
(3)
1013.2813.2565,433–––65,4332018928
(8)
1013.2813.2539,260–––39,26020181130
(3)
1011.0711.7911,028–––11,02820181231
(3)
1010.5317.3410.79133,263–26,247–107,01620181231
(8)
1010.5315.4510.7912,727–533–12,1942019125
(3)
109.6210.4438,649–––38,6492019228
(3)
1010.7718.5410.5415,600–15,600––201935
(3)
1011.6811.5178,494–––78,4942019510
(3)
109.3310.3244,213–––44,213201965
(3)
109.2517.259.232,394,600–517,81611,5441,865,240201965
(5)
109.259.23129,220–––129,2202019628
(3)
109.679.53–––––2019830
(3)
1011.1420.0011.0697,201–17,901–79,30020191129
(3)
1015.7115.83–––––20191231
(3)
1012.8017.6012.9215,834–15,834––202033
(3)
1012.6212.19–––––
?2023
(1)(2)
2023
202312312020331
(3)
109.659.67294,775–––294,7752020512
(3)
1012.5612.18–––––2020529
(3)
1012.4912.73–––––2020617
(3)
1013.3318.1513.421,543,243–326,01435,0481,182,1812020617
(5)
1013.3313.4290,766–––90,7662020630
(3)
1014.5514.66212,771–––212,771202087
(3)
1017.2416.9940,248–––40,2482020831
(3)
1018.6918.85––––––2020930
(3)
1021.6522.038,021–––8,0212020116
(3)
1023.0823.07175,708––4,0828,632162,99420201130
(3)
1021.9920.9915,756––––15,7562021122
(3)
1027.4628.8155,263–––55,2632021226
(3)
1025.3625.816,331–––6,3312021331
(3)
1025.6126.78148,824–––148,824202157
(3)
1024.1524.7884,240–––84,2402021528
(3)
1027.0027.58121,485–––121,4852021616
(3)
1025.5426.531,878,695––108,680161,2781,608,737
?2023
(1)(2)
2023
202312312021616
(5)
1025.5426.5317,498––––17,4982021630
(3)
1027.4827.2859,397––5,4215,86348,113202186
(3)
1025.8425.61150,423––40,65141,43168,3412021831
(3)
1023.2223.72153,322–––153,3222021930
(3)
1027.8128.7357,018–––1,56055,4582021115
(3)
1028.3828.0845,786–––22,55523,23120211130
(3)
1026.4026.8564,649–––64,64920211231
(3)
1021.0320.8459,332––12,36320,33226,6372022127
(3)
1017.2718.61371,059–––371,0592022228
(3)
1016.4718.8116.22171,626–3,83512,1684,043151,5802022331
(3)
1015.8515.46135,694–––135,694202256
(3)
1012.2714.3112.5080,821–5,82411,64863,3492022531
(3)
1010.3010.56123,604–––123,6042022622
(3)
1011.7415.4111.985,816,690–162,162552,4395,102,0892022622
(9)
1011.7411.9811,804–––11,8042022630
(3)
1012.4814.9712.8177,974–3,757–74,2172022831
(3)
1012.7313.3222,009–––22,009
?2023
(1)(2)
2023
202312312022930
(3)
1010.4815.3410.5866,690–3,666–63,02420221110
(3)
1013.5614.5254,106––7,93046,17620221130
(3)
1013.8414.7417,745–––17,74520221230
(3)
1017.2217.267,592–––7,5922023125
(3)
1020.5220.64–29,471––29,4712023228
(3)
1016.6217.28–61,724––61,7242023331
(3)
1016.6716.99–63,765–11,92151,844202355
(3)
1020.0520.06–31,837–13,44218,3952023531
(3)
1017.5617.98–19,188––19,1882023615
(3)
1016.0116.41–5,314,374–130,8455,183,5292023630
(3)
1013.7413.82–30,277––30,277202383
(3)
1014.6016.08–66,729––66,7292023831
(3)
1016.2515.97–54,314––54,3142023929
(3)
1014.1714.51–192,686––192,68620231113
(3)
1015.3215.30–24,297––24,29720231130
(3)
1014.0914.38–32,968––32,96820231229
(3)
1013.8113.87–50,271––50,271
58,683,1449,817,9255,759,143958,191266,97561,516,760
?2023
* Anthony C. Hooper2023417* Thomas Malley2024122
(1) 13
(2) 13
(3) 25%
75%25%36(4)(5)
Thomas Malley2024122ThomasMalley20241232023615Thomas Malley20241232024630
(6) 20%80%20%48
(7) 48(8)
(9) 50%50%50%12
(10) Thomas Malley2024122Thomas Malley
Thomas Malley
?2023
2016
(3)
1,349,9072023615(1)16.41–16.0110,999,987
327,2492023615(1)16.41–16.012,666,654Anthony C. Hooper26,9752023615(2)16.41–16.01199,963Margaret Han Dugan26,9752023615(2)16.41–16.01199,963Donald W. Glazer26,9752023615(2)16.41–16.01199,963Michael Goller26,9752023615(2)16.41–16.01199,963Ranjeev Krishana26,9752023615(2)16.41–16.01199,963Thomas Malley*26,9752023615(2)16.41–16.01199,963Corazon D. Sanders26,9752023615(2)16.41–16.01199,963Alessandro Riva26,9752023615(2)16.41–16.01199,963
26,9752023615(2)16.41–16.01199,963
760,8512023615(1)16.41–16.016,199,947
409,0582023615(1)16.41–16.013,333,291
507,2342023615(1)16.41–16.014,133,298Chan Lee248,9502023615(1)16.41–16.012,028,619
5,971,901
2023125
20231229(1)
13.82-
20.64–
13.74-
20.5248,738,046
9,817,92583,379,092
* Thomas Malley2024122
(1) 25%
75%25%36
?2023
(2)
10Thomas Malley2024122Thomas Malley20241232023615Thomas Malley20241232024630
Thomas Malley(3)
201620231231201615,8992016
20179262023122920231155,397,173201620231231201666,401,023
2023
20231231
2023(1)
2018430(6)13.37–––––– 2018626(6)12.70––––––
2021616(6)25.54109,694–36,556–73,13815.46
2022622(6)11.74334,009–83,499–250,51014.28
2023615(6)16.01–355,641––355,641–
2018626(6)12.70––––––
2021616(6)25.5429,250–9,750–19,50015.46
2022622(6)11.7483,499–20,865–62,63414.28
2023615(6)16.01–86,216––86,216–Anthony C. Hooper2021616(7)25.547,800–7,800––13.87
2022622(7)11.7416,692–––16,692–
2023615(7)16.01–12,922––12,922–
?2023
2023
20231231
2023
(1)Margaret Han Dugan2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Donald W. Glazer2021616(7)25.547,800–7,800––13.87
2022622(7)11.7416,692–––16,692–
2023615(7)16.01–12,922––12,922–Michael Goller2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Ranjeev Krishana2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Thomas Malley*2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Corazon D. Sanders2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Alessandro Riva2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–
2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–
?2023
2023
20231231
2023
(1)
2018430(6)13.37230,009–230,009––19.61201965(6)9.25108,368–108,368––17.492020617(6)13.3367,093–33,527–33,56615.402021616(6)25.5458,500–19,500–39,00015.462022622(6)11.74187,876–46,969–140,90714.282023615(6)16.01–200,447––200,447–2020630(6)14.5527,612–13,793–13,81913.742021616(6)25.5421,515–7,163–14,35215.462022228(6)16.4761,750–15,431–46,31916.622022622(6)11.74104,377–26,091–78,28614.282023615(6)16.01–107,770––107,770–2018626(6)12.70––––––201965(6)9.2518,993–18,993––17.492020617(6)13.3346,592–23,283–23,30915.402021616(6)25.5440,222–13,403–26,81915.462022622(6)11.74125,255–31,304–93,95114.282023615(6)16.01–133,627––133,627–Chan Lee
2022729(6)13.45116,012–29,003–87,00916.122023615(6)16.01–65,585––65,585–
2018131 20211231
(6)18.5518,205,967–8,433,3341,470,5868,302,047(2)202211 20221231
(6)12.2835,222,434–8,496,7742,826,09623,899,564(3)202311 202312
(6)15.62–33,499,7652211,410,86432,088,680–
?2023
2023
20231231
2023(1)
201924 20211231
(6)12.018,684–8,684––(4)202211 20221231
(8)17.7023,634–23,634––13.87202311 20231231
(8)13.81–8,645––8,645
55,397,17334,573,99417,862,5985,707,54666,401,023
* Thomas Malley2024122
(1) 13
(2) 1310.1016.92
(3) 1316.92
(4) 1310.1016.92
(5) 1316.92
(6) 25%
(7)
Thomas Malley2024122Thomas Malley(8)
?2023
(3)
355,6412023615(1)–16.015,499,85186,2162023615(1)–16.011,333,297Anthony C. Hooper12,9222023615(2)–16.01199,834Margaret Han Dugan12,9222023615(2)–16.01199,834Donald W. Glazer12,9222023615(2)–16.01199,834Michael Goller12,9222023615(2)–16.01199,834Renjeev Krishana12,9222023615(2)–16.01199,834Thomas Malley*12,9222023615(2)–16.01199,834Corazon D. Sanders12,9222023615(2)–16.01199,834Alessandro Riva12,9222023615(2)–16.01199,834
12,9222023615(2)–16.01199,834200,4472023615(1)–16.013,099,836107,7702023615(1)–16.011,666,622Chan Lee65,5852023615(1)–16.011,014,247
133,6272023615(1)–16.012,066,490
33,499,765202311
20231229
(1)–15.62521,586,9508,64520231229(4)–13.81119,93934,573,994558,526,987
* Thomas Malley2024122
(1) 25%
(2)
Thomas Malley2024122Thomas Malley(3)(4)
?2023
3. 2018
201811720181272018
20186620182019652018202162018202191
2018201815%20182018
201820185%2018
1%10%25,000
?
2023
3191
2018
85%2018
2018
?2023
20187,355,31520231120183,666,071202311
2022911,724,996201820231231
20244171,941,075919,678201820231231202312312023
20187,355,31520231120183,666,0712022912023311,724,99620182023123120244171,941,075919,67820244
170.07%2018
2018
2018202191201812720184.5
2018
2022912023313,0393,218
2018
?2023
2018
202291
202291
(1)(2)
202291611.1910,626.7610,617
11.19
202291611.1910,403,11910,403,119
11.19
929,90310,413,736
1. 20229113.20103.60
12,251,44496,153,7432022912018
2. 202291
2018202322811.19930,8522023228
17.28135.5816,084,407126,195,362
3. 20229110,413,736
930,852
4. 2018
?2023
2023
2023
(1)(2)
202331613.579,1749,174
13.57
202331613.5711,236,09311,236,093
13.57
793,46811,245,267
1. 20233117.28135.64
14,411,089113,103,7002023312018
2. 202331
2018202383113.57794,2352023831
15.97125.3312,678,81499,483,176
3. 20233111,245,267
794,235
?2023
2018
BMS-Celgene23,273,1082023822023111
?2023
Anthony C. Hooper2023417Olivier BrandicourtCorazon (Corsee) D. Sanders2023913Anthony C. HooperThomas MalleyThomas Malley2024122Malley2024123Olivier Brandicourt
MalleyOlivier Brandicourt
202412320231231
13.2013.2113.22
2024417
?2023
2018882023
2024
2024417
?2023
20231231
C1C.2.1
Ranjeev Krishana
?2023
3.21D.3.3D.3.7
Anthony C. Hooper2023417Olivier BrandicourtCorazon (Corsee) D. Sanders2023913Anthony C. HooperThomas MalleyAnthony C. Hooper
3.10(2)3.21Thomas Malley2024122Thomas Malley2024123OlivierBrandicourtMalleyOlivier Brandicourt2024123
3.25E.1.2
Margaret HanDuganRanjeev KrishanaMargaret Han Dugan
3.27AB.3.1
Donald W. GlazerMichael GollerAnthony C. Hooper2023417Alessandro RivaDonald W. Glazer
?2023
C3B.8
202311
?2023
20231231
*Olivier BrandicourtMargaret Han DuganDonald W. GlazerMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders* 2024123Olivier Brandicourt
Anthony C. Hooper20234172023416Anthony C. Hooper2024122Thomas MalleyMalley
MalleyMalley
?2023
2023202312313.13
20262024
2025
?2023
?2023
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2023
??
Anthony C. Hooper2023417Olivier Brandicourt2024123Corazon (Corsee) D. Sanders2023913Anthony C. Hooper
Thomas Malley2024122Thomas MalleyAnthony C. HooperCorazon(Corsee) D. Sanders3.10(2)3.21
2023123112
www.beigene.com HKEX investors2023
202220232023
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?2023
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Margaret Han DuganRanjeev KrishanaMargaret Han Dugan2023123125
15,000,001135,000,000
?2023
20231231253www.beigene.com HKEXinvestors2023
20162018
???????
Donald W. GlazerMichael GollerAnthony C.HooperAlessandro RivaDonald W. Glazer
?2023
20231231
www.beigene.com HKEX investors
20232023
3.13
???
20231231
Margaret Han DuganMichael GollerAlessandro RivaCorazon (Corsee) D.SandersAlessandro Riva2024122Thomas Malley www.beigene.com HKEX investors
?2023
????
20231231
Anthony C. HooperOlivier Brandicourt2024319Margaret Han DuganRanjeev KrishanaCorazon (Corsee)D. SandersAnthony C. Hooperwww.beigene.com HKEXinvestors
?2023
20202022 www.beigene.com HKEX investors
2024417
LGBTQ+1
2023
202233%202338%202252%202355%
?2023
2021
?2023
(Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, Camana Bay,Grand Cayman KY1-1108, Cayman Islands(a)(b)
193414a-8(b)(2)(c)(d)(e)(f)(i)(ii)
(g)
?2023
A.2.1
20231231
?2023
20231231
5/51/15/54/40/1Margaret Han Dugan5/56/74/44/41/1Donald W. Glazer5/54/41/1Michael Goller5/53/44/41/1Anthony C. Hooper
(1)
4/512/124/44/41/1Ranjeev Krishana5/57/74/41/1Thomas Malley
(2)
5/511/122/41/1Alessandro Riva5/54/44/41/1Corazon (Corsee) D. Sanders5/511/124/44/41/1
4/57/74/41/1
(1) Anthony C. Hooper20234172023913Anthony C. Hooper
(2) 2024122Thomas Malley
?2023
C.2.720231231
2023123120231231
?2023
20231231Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. HooperRanjeev KrishanaThomas MalleyAlessandro RivaCorazon (Corsee) D. Sanders2024123Olivier Brandicourt20241Olivier BrandicourtOlivier Brandicourt(i)2024112
3.09D(ii)
202320221231Ernst& Young LLP
202320227,0577,03764577,1217,09410-Q2023
?2023
201910312020
???
18.2%14A14A
????
12.5
?2023
sotorasib (AMG 510)
AMG 51020232(i)2023112023831AMG 510(ii)AMG 510
14A.52
14A.53(1)14A.5214A.53(1)(a) 14A(b)(c)(d)
14A.5514A.56(e) 2019111
?2023
(a)
= 50% x(b)?
(i)(ii)(iii)(x)
(y)20AMG
= x?
= x
?2023
12.5
1,2503,750
(a)(b)(c)
14A.563000
2023123120231231(a)(b)
(c)
?
2023
20203172020924
20.6%
20.4%(i)
(ii)2020121(a)
20%(b)60(c)2023121
20203182020925202010
20219165,5292,151,87750,000,00020222023
?2023
20236152023201627,3576,632
Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. HooperRanjeev KrishanaThomas MalleyAlessandro RivaCorazon (Corsee) D. Sanders994
558,155
2023418202362020234272023123114A.71
2,069,546
399.43137
2023123126
14A
?2023
Committee of Sponsoring Organizations of the Treadway Commission2013
?2023
?2023
????
(i)(ii)
?2023
20231231
D.2.3
Chan Lee202312313.29
6162
?
2023
(Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, Camana Bay, Grand CaymanKY1-1108,Cayman Islands
(Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, CamanaBay, Grand Cayman KY1-1108, Cayman Islands[]
(i)(ii)(iii)(iv)(v)(vi)
?2023
2023123120231231
2024228www.beigene.com
10-K
2024
202112152023615
A1
2023427( www.hkexnew.hk )
2023616
?2023
273367
20231231
20231231
IESBAIESBA
?2023
20231231
1,778.620231231
163.0
?2023
?2023
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2024328
?2023
123120232022
3,171,8003,869,564 411,473196 52,600665,251 6358,027173,168 7416,122282,346 12243,392216,553
4,203,4145,207,078 91,324,154845,946 895,207109,960 1057,13840,616 12125,362175,690
1,601,8611,172,212
5,805,2756,379,290
13315,111294,781 12693,731467,352 3–213,861 1122,95125,189 821,95024,041 368,004114,335 14688,366328,969
1,810,1131,468,528
?2023
123120232022
14197,618209,148 330042,026 822,25134,517 1116,49415,996 3170,662179,625 1250,51046,095
457,835527,4072,267,9481,995,935
0.0001 9,500,000,000 202320221231 1,359,513,2241,356,140,180135135 11,598,68811,540,979 19(99,446)(77,417) (7,962,050)(7,080,342)
3,537,3274,383,3555,805,2756,379,290
?2023
123120232022
152,189,8521,254,612 3268,927161,309 2,458,7791,415,921
379,920286,4752,078,8591,129,446 1,778,5941,640,508 1,504,5011,277,852 103,500751 3,286,5952,919,111
(1,207,736)(1,789,665) 74,00952,480 5307,891(223,852)
(825,836)(1,961,037)1155,87242,778
(881,708)(2,003,815)17(0.65)(1.49)171,357,034,5471,340,729,572
(8.45)(19.43)104,387,273103,133,044
?2023
123120232022(881,708)(2,003,815)
19(25,464)(90,421)22(5,611)365199,046(5,311)
(903,737)(2,099,182)
?2023
123120232022
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(1,157,453)(1,496,619) (561,896)(325,434) (2,075)(1,485) 673,2401,563,618 (15,000)(143,665) 10(19,365)– 5(14,900)(15,911)
60,0041,077,123
?2023
123120232022
1422,50237,372 14661,530313,774 14(323,266)(417,081) 55,71246,964
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?2023
202112311,334,804,28113311,191,00717,950(5,076,527)6,132,563
––(152)––(152)1,375,621–––––19,960,278246,962––46,964
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620,000,000
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BeiGene USA
1100%
BeiGene AUS Pty Ltd
BeiGene Australia
56,947,230100%
BeiGene Switzerland GmbH
BeiGene Switzerland
20,000100%
BeiGene Hopewell Urban
Renewal, LLC
507,943,128100%
*
?2023
2.
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2.
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202312317,529,00020221231
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20202022
202320221231
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2.
20231231
202320221231
202320221231
?2023
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20231231123
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20221231123
758,114––
665,251––
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1,426,6727068,190
?2023
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Leap Therapeutics, Inc.Leap2020120219LeapLeap1Leap2
202312311,492,00020221231202320221231
?2023
2.
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(iv)(v)
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?2023
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4590
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?2023
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20232022123134,084,00038,118,0002023202212312,938,0003,169,000
202320221231120,00058,00020232022123101,664,000
?2023
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2023202212313,171,800,0003,869,564,000
2023202212312,600,000665,251,000202320221231202320221231358,027,000173,168,000
20231231ASD Specialty HealthcareMcKesson
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202320221231
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300,000,000
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2023
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Anthony C. Hooper2020120231
?2023
3.
132.74
2,109,902,000
601,857,000
2,779,241,0002,162,407,000616,834,000
202320221231
12312023202253,31498,95555,29496,402108,608195,357
20231231483,651
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202320221231
12312023202268,004114,335170,662179,625238,666293,96020231231
1231202320228,3585,898(60,917)(54,865)1,688(1,216)(50,871)(50,183)202320221231108,691,00071,720,00020232022123155,474,00054,064,000
2023123118.2%14A
?2023
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202320221231
12312023202246,80068,665
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202311
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20231231
?2023
3.
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LY0100520221248,665,000
30,000,0002023123119,365,000Shoreline Biosciences, Inc.20216Shoreline BiosciencesInc. ShorelineShoreline
ShorelineShorelineShorelineShoreline2022145,000,000
20211231Shoreline2024
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503,750,000Assembly
20201231202312Assembly
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20209102020918?20201020,000,000145,000,00020201231202111
?
2023125,000,000
?2023
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202320221231
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202320221231
12312023202211,473196
2,7115,27714,1845,473
202312311,191,583,000
?2023
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20231231
2,56535–2,6002,56535–2,60020221231
674,262–9,011665,251674,262–9,011665,2512023123120231231
20231231
?2023
5.
Leap Therapeutics, Inc.20201Leap Therapeutics, Inc. Leap5,000,000Leap BB20203Leap
Leap20219Leap
7,250,000Leap20231231Leap2.9%
4.7%
Leap
123120232022
42530,102202320221231
123120232022Leap3,0463,307Leap542706
?2023
5.
20232022123155,860,000
57,054,000
123120232022(6,448)5,065
20232022123125,981,00027,710,000
1231202320227,8563,682
?2023
6.
123120232022360,053173,379(2,026)(211)358,027173,16830120
1231202320226356,243172,6336121,784535
358,027173,168
12312023202211211415
161,861(219)
(43)–
(3)15
12312,026211
?2023
7.
123120232022148,77288,95739,09820,886228,252172,503416,122282,346
8.
503630
12312023202225,97825,9386,1016,8341,6831,29933,76234,071
?2023
8.
12312023202243,49056,00851,71753,95295,207109,96021,95024,04122,25134,51744,20158,558
2024123123,4992025123114,148202612315,740202712313,155202812311,682
49,156(4,955)44,201
?2023
8.
12312023202227,98528,06411,85422,278123120232022
7.22%5.76%
9.
12312023202265,48565,485205,349158,90860,12453,786231,656222,448186,856175,67983,28147,483832,751723,789(249,212)(171,470)740,615293,6271,324,154845,946
?2023
9.
202320221231
123120232022579,649224,392119,38033,33216,13512,25625,45123,647740,615293,62720232022123180,436,00062,302,000
10.
202320221231
2023123120221231
64,274(7,807)56,46741,235(4,119)37,1168,987(8,316)6718,316(4,816)3,50073,261(16,123)57,13849,551(8,935)40,616
?2023
10.
1231202320223,7393,2253,5007517,2393,97620231231
123120244,7762245,00020254,7762245,00020264,7762234,99920274,776–4,77620284,776–4,776202932,587–32,587
56,46767157,138
?2023
11.
123120232022117,44667,744(315,852)(583,610)(627,430)(1,445,171)(825,836)(1,961,037)
123120232022
25,1704,84424,95627,9055,0596,54755,18539,296
6873,480
–26873,48255,87242,778
?2023
11.
123120232022(825,836)(1,961,037)21%21%(173,426)(411,818)141,902209,692
19,13429,22332,58133,872(3,464)1,375845,811229,550(704,928)–(64,343)(42,844)(37,395)(6,272)55,87242,778(6.8)%(2.2)%
?2023
11.
123120232022106,70897,896996,588862,21426,68719,70068,11786,000704,928–687,600798,5637,89310,348164,19063,156(7,735)(10,098)2,754,9761,927,779(2,771,470)(1,943,775)(16,494)(15,996)
20231231
?2023
11.
202320221231
123120232022111,943,7751,758,409
845,811229,550(18,116)(44,184)12312,771,4701,943,7752023202212315,945,753,0005,077,247,000
20231231202420331,839,748,000202520304,088,658,000
2,047,00076,794,00020362043704,928,0002028202320221231
1231202320221111,5559,925
2,7091,630123114,26411,555
2023123112
?2023
11.
202320221231
202312312013202320132023
2020202320152023
201320232025202312313,092,0000.0120231231
2,969,00012.
12312023202260,47671,48837,32020,47836,12422,777
1,7353,0398,8723,66442,06658,95056,79936,157243,392216,553
?2023
12.
1231202320224,14422,025(1)
18,12248,6422,5468048,1957,0542,7115,27789,64491,779
–109125,362175,690
(1)
123120232022217,803184,775162,969139,16887,57251,80630,08318,815139,93641,81755,36830,971693,731467,352
?2023
12.
12312023202234,20438,17614,9957,7601,127–
18415950,51046,09513.
202320221231
1231202320223302,310290,284368,2052,570614,5511,379145548
315,111294,781
?2023
14.
202320221231
123120232022201844580,0009202744(1)14,089100,0007,25050,0002020122(2)92029120(2)8,85662,8571,45010,0002020119378,00092029118(3)5,63640,0005,43737,5002023728380,000120241225(4)300,0002,129,321––20231220150,0001202412197.3%150,0001,064,660––2020924200,000(5)––150,0001,034,554202222550,000120232252.2%––50,000344,851202365400,00012024643.2%56,356400,000––202354340,0001202453(6)47,903340,000––2023530200,000120245292.8%28,177200,000––20231114700,0001202411212.9%49,312350,000––
(7)
28,037199,000114,832792,000688,3664,885,838328,9692,268,905201844580,0009202744(1)59,174420,00075,395520,0002020122(2)92029120(2)37,638267,14347,847330,0002020119378,00092029118(3)42,337300,50049,369340,5002022729480,000102032728(8)58,469415,00036,537252,000
197,6181,402,643209,1481,442,500
?
2023
14.
1. 202312314.5%202312316,987,00050,000,000
2. 2020122
1,100,000,000
202112311,100,000,000350,000,00020231231
4.1%202312311,422,00010,000,000
201733
3. 202312313.9%
202312315,281,00037,500,000
4. (SOFR)20231231
7.2%
5. 20209200,000,000120,000,00080,000,000
202110820211082022108202293020231231150,000,000
6. 202312314.5%
7. 20231231
875,000,00020221215202452420231231
28,174,000199,000,000109,576,000792,000,000202312313.2%2024
8. 20227
480,000,000202312313.9%2023123122,502,000163,000,000
?2023
14.
202312
20231231
20241231688,3662025123135,5652026123146,2792027123146,2792028123125,146
44,349885,984
20232022123120,800,00021,699,00016,571,0002,594,000
?2023
15.
?????????
202320221231
1231202320222,718,9691,438,440
(529,117)(183,828)2,189,8521,254,612202320221231
123120232022?
1,290,396564,651?
536,620422,885?
76,01879,049?
92,82863,398?
56,54738,124?
54,34236,107?
39,79913,696
?
13,96015,213
?
6,6685,460
22,67416,0292,189,8521,254,612
?2023
15.
202320221231
1231202320221141,81759,639
529,117183,828(430,998)(201,650)1231139,93641,817
16.
123120232022
379,920286,475980,43662,302
1,778,5941,640,508825,97825,938107,2393,976
7,1217,094 1,120,4031,000,890 18367,588303,162 62,09250,358
1,550,0831,354,410
64,760233,81261,861(219)
2,9641,140(78,373)(74,234)
202320221231699,289,000602,585,000
?2023
17.
123120232022
(881,708)(2,003,815) 1,357,034,5471,340,729,572 (0.65)(1.49)
202320221231
202320221231
?2023
18.
201620161201620162016265,029,5952016
201120112016
201120231231201120165,166,8222016201711
(i)(5%)(ii)
20181129,603,6162016201882016201812201638,553,159202062016
57,200,0002030413201620231231201637,575,472
20162016
201666,300,00020223315%2022622
?2023
18.2018201862018201812,000,000
5635(c)(4)5635(c)(4)20182018
20162018
201820162018202262220182018620183,500,000
201882018123,855,3157,355,3156
15%
10%
?2023
18.
2018
2023831794,144207.5515.97176.4213.5710,7772023228930,582171.1013.16145.4411.1910,4142022831861,315171.6613.20145.9111.229,6672022228667,160210.5216.19178.9413.769,1832021831425,386308.3023.72262.0620.168,5752021226436,124236.3018.18200.8615.456,738
202312311,941,075
?2023
18.
201120162018
2021123172,204,8887.08 12,516,81612.346.40 (5,898,217)4.6352,258 (2,296,634)16.462022123176,526,8537.85 9,817,92516.378.14 (6,974,331)4.5492,051 (1,225,334)17.602023123178,145,1139.065.09465,2312023123159,221,0916.933.91452,7502023123175,306,5108.814.95463,359
2023123116,085,41996,053,0002.5
?2023
18.
20232022123161,121,00062,548,000
123120232022
7.26~ 10.725.51~ 9.04
3.4% ~ 4.6%1.8% ~ 3.9%
2.82.858% ~ 60%51% ~ 60%
0%0%1010
20232022123120231231
?2023
18.
20162018
2021123136,082,98218.33 38,707,66912.46 (12,533,586)16.37 (6,859,892)16.722022123155,397,17314.87 34,573,99415.57 (17,862,598)14.71 (5,707,546)15.472023123166,401,02315.222023123156,440,87015.22
20231231702,778,000
2.8
202320221231
123120232022163,550139,348204,038163,814367,588303,162
?
2023
19.
2021123127,898(3,700)(6,248)17,950
(90,421)(5,311)(446)(96,178)(1)
––811811
(90,421)(5,311)365(95,367)20221231(62,523)(9,011)(5,883)(77,417)
(25,464)9,046(6,422)(22,840)(1)
––811811
(25,464)9,046(5,611)(22,029)20231231(87,987)35(11,494)(99,446)(1)
?2023
20.
BMS202381BMS-Celgene
ABRAXANE
?
20172018BMS-Celgene
201723,273,108
20231231
??20241231
2023815362,917,000
20231231
21.
10%50%
?2023
21.
202320221231
10%
2023202212314,125,458,0003,548,881,000
22.
20232022123194,358,00083,860,000401(k)401(k)401(k)
401(k)20234%202320221231
401(k)15,316,00010,298,000
?2023
22.
2023202212312,710,0003,887,000
20232022123170,600,00045,835,00055,605,00038,075,000
20211231
20233,577,000
20231231
2024123160720251231214202612315802027123198520281231811
9,56912,766
?2023
23.
20231231169,212,00041,186,000128,026,000BMS
BMS
20231231333,498,000
1,250,000,00020231231
483,651,000
15,055,000202312318,905,000
(CRO)
?2023
24.
383(1)(a)(b)(c)(f)2202320221231
123120232022856795 1,275910 1,1321,120 *17,98117,760 –14
20,38819,80421,24420,599
* 2425
202320221231
?2023
24.(a)
20232022123120231231
Thomas Malley101––405–506Donald W. Glazer81––405–486Michael Goller82––405–487Ranjeev Krishana87––405–492
87––405–492Corazon (Corsee) D. Sanders102––405–507Alessandro Riva92––405–497Margaret Han Dugan111––405–516Anthony C. Hooper
(1)
113––405–518856––3,645–4,501
Anthony C. Hooper20234172023416Anthony C. Hooper2023416Anthony C. Hooper
?2023
24.
(a)
20221231
Thomas Malley93––391–484
39––210–249Donald W. Glazer74––391–465Michael Goller77––391–468Ranjeev Krishana79––391–470
85––391–476
6––(190)–(184)Corazon (Corsee) D. Sanders96––391–487Alessandro Riva
71––330–401Margaret Han Dugan
77––330–407697––3,026–3,723
1. 2022622
2. 2022131
3. Alessandro Riva202221
4. Margaret Han Dugan202221
?2023
24.
(b)
202320221231
202320221231
123120232022
–– 1,275910 1,1321,120 14,33614,343 –14
16,74316,3872023123120221231
Anthony C. Hooper2023202212312620231231
267–1503,854–4,271
?2023
24.
(b)
20221231
100–1503,989–4,239Anthony C. Hooper98––391–489
198–1504,380–4,72825.
202320221231
20232022
1231202320222,2231,9911,6441,43318,87418,653
173722,75822,114
?2023
25.
2023202225,000,00130,000,000–135,000,00140,000,0001–45,000,00150,000,000–150,000,00155,000,0001–90,000,00195,000,0001100,000,001105,000,000–1
202320221231
26.
202320221231
20231231(i)100,0002022100,000(ii)150,0002022150,000(iii)(HSR)167,000
100,00067,000(iv)327,2492022471,913
2,667,00020223,000,000(v)86,216202283,4991,333,000
20221,000,000
14A
?2023
27.
1231202320221,128,219502,626945,551389,710182,668112,9161,101,951840,0321,093,091840,0328,860–202,01463,257122,22814,864
79,78648,39326,59510,00628,98210,006(2,387)–2,458,7791,415,921
?2023
28.
20231231
(i)(iii)(1,778,594)(31,745)1,344(1,808,995)(1,504,501)(21,942)1,659(1,524,784)74,009–(3,082)70,927(825,836)(53,687)(79)(879,602)
(55,872)(15,000)–(70,872)(881,708)(68,687)(79)(950,474)
20221231
(i)(iii)(1,640,508)(14,697)471(1,654,734)(1,277,852)(19,296)366(1,296,782)52,480–(3,142)49,338(1,961,037)(33,993)(2,305)(1,997,335)
(42,778)10,311–(32,467)(2,003,815)(23,682)(2,305)(2,029,802)
?
2023
28.
20231231
(i)(ii)(iii)95,207––(2,384)92,8235,805,275–(2,384)5,802,89111,598,68868,687––12,183,311
208,042*307,894*–(7,962,050)(68,687)–(79)(8,549,057)
(208,042)*(307,894)*(2,305)*3,537,327–(2,384)3,534,943
20221231
(i)(ii)(iii)109,960––(2,305)107,6556,379,290–(2,305)6,376,98511,540,97933,993––12,056,915
174,049*307,894*–(7,080,342)(33,993)–(2,305)(7,598,583)
10,311––
(184,360)*(307,894)*–4,383,355–(2,305)4,381,050*
?2023
28.
(i)
2023123153,687,000202233,993,000
(ii)
20162307,894,000
307,894,000
?2023
28.
(iii)
201911
?
2023
29.
123120232022
723,9641,742,320 58451 2,600548,303 1,244,790804,471
1,971,9383,095,145 1,889,063914,653 5,4227,510 5,6256,328 1,624,6901,621,824
3,524,8002,550,315
5,496,7385,645,460
561,827446,362 29,38757,316 68,004114,335 910,131297,868
1,569,349915,881
?2023
123120232022
170,662179,625 219,400166,599
390,062346,2241,959,4111,262,105
0.00019,500,000,000 202320221231 1,359,513,2241,356,140,180135135 11,598,68811,540,979 (99,446)(77,417) (7,962,050)(7,080,342)
3,537,3274,383,3555,496,7385,645,460
29.
?2023
29.
202112311,334,804,28113311,191,00717,950(5,076,527)6,132,563
––(152)––(152)1,375,621––––– 19,960,278246,962––46,964
––303,162––303,162
–––(95,367)–(95,367)
––––(2,003,815)(2,003,815)202212311,356,140,18013511,540,979(77,417)(7,080,342)4,383,355
84,227––––– 26,561,925253,006––53,008
(23,273,108)(2)(362,915)––(362,917)
––367,618––367,618–––(22,029)–(22,029)––––(881,708)(881,708)202312311,359,513,22413511,598,688(99,446)(7,962,050)3,537,327
?2023
30.
202312312022123131.
2024328
?2023
2011201141520154172011201620181272016
2022429201820182021616
20219120182018
20186620188720182022622ADS13
198747
20191031202012
201910312023615
20101028
?2023
2017125
201733BeiGene Switzerland GmbH201791BLABMS-CelgeneCelgene Switzerland LLCCelgene
Kappa Holdings LLCCelgene Holdings East Corporation
CMO
C1CRO
?2023
EMA(European Medicines Agency)
EUSAEUSA PharmaFDA(U.S. Food and Drug Administration)
(General Data Protection Regulation)(EU)2016/679
19981127
?2023
GEMC3
NMPA(National Medical Products Administration)
Novartis Pharma AGNRDL
201873020231231
2016sBLA
?2023
sNDA
?2023
BRAFB-raf
BTK
BcHLCLL
FcγFcγ
MCLNSCLCPARPADPDNA
DNAPD-11Tpro-B
PD-L1PD-L2PD-1T
?2023
SLLTTT
BTIM-3T3Th1
UCWM