2023
中期報告
?2023
2 4 7 35 82 83 84 86 87 89 143 147
?2023
Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. Hooper*Ranjeev KrishanaThomas MalleyAlessandro RivaCorazon (Corsee) D. Sanders
Anthony C. Hooper
Thomas MalleyCorazon (Corsee) D. Sanders
Margaret Han DuganRanjeev Krishana
Donald W. GlazerMichael GollerAnthony C. HooperAlessandro Riva
Alessandro RivaMargaret Han DuganMichael GollerThomas MalleyCorazon (Corsee) D. Sanders
Anthony C. HooperMargaret Han DuganRanjeev KrishanaCorazon (Corsee) D. Sanders
* Anthony C. Hooper20234172023416
Anthony C. Hooper
1. 2023913
?
2023
(FCG, HKFCG)Vistra Corporate Services (HK) Limited
Ernst & Young LLP
Mourant Governance Services (Cayman) Limited94 Solaris AvenueCamana BayGrand Cayman KY1-1108Cayman Islands
Mourant Ozannes
171712-1716
Mourant Governance Services (Cayman) Limited94 Solaris Avenue, Camana BayGrand Cayman KY1-1108Cayman Islands
06160
www.beigene.com
?2023
????????????
?2023
?????????????? ADS
?? 20221231
?2023
?2023
?
(BTK)
?
PD-1
?
PARP1PARP2
???
1204521,00035
CMO
2010
10,000
?2023
2023721
??2023712FDA
??
(R/R)(FL)FDAFDA20242023710ADC2023710TIGIT
202374
?
2023630
2023530
?
CLL202356
?CLLSLL
?2023
1. 1,100
??
?
CLL
BCL-2sonrotoclax(BGB-11417)HPK1BGB-15025BTK(CDAC)BGB-16673OX40LAG-3TIM-3
CDACADCCAR-NKmRNA2023
2. 3,000
(CRO)75%
3.
??
?29355,000
800ALPINE
?BTK2022(ASH)
?2023
?
BCL-2sonrotoclax
PD-1
??
PD-1/PDL-1
?
OX40TIGITLAG-3TIM-3
4. 3,500
??BTKPD-1/PDL-1
???
5.
2023
?2023
20211(1)
(2)
202112
TIGIT
?????
(1)(2)
(3)
?2023
20237
??
?2023
??????
?
?
BTK?
?
PD-1? TIGIT? Sonrotoclax(BGB-11417)Bcl-2? BGB-16673BTK(CDAC)?
?
PARP1PARP2? BGB-150251(HPK1)? BGB-A445OX40? Surzebiclimab(BGB-A425)TIM-3? BGB-10188PI3Kδ? LifirafenibRAF? BGB-24714(SMAC)
?2023
? BGB-B167(CEA)4-1BBCEA×4-1BB? LBL-007LAG-3
2023630
2BGB-23339
?? Mirati Therapeutics, Inc.? ZW25(Zanidatamab)Zymeworks Inc.HER2
????
?2023
???????
?2023
ADS
202112
?2023
20232022630
20232022%
964,036566,084397,95270.3% 79,02682,114(3,088)(3.8)% 1,043,062648,198394,86460.9% 177,779136,41041,36930.3% 831,348768,12263,2268.2% 723,533625,97697,55715.6% 375376(1)(0.3)% 1,733,0351,530,884202,15113.2%
(689,973)(882,686)192,713(21.8)% 31,08621,5029,58444.6% (45,515)(117,650)72,135(61.3)%
(704,402)(978,834)274,432(28.0)% 25,16622,0903,07613.9%
(729,568)(1,000,924)271,356(27.1)%
2022
1.2.
?2023
20232022630
202363020226306.48260.9%
10.431
??20232022630
20232022%964,036566,084397,95270.3% 20,38024,240(3,860)(15.9)% 52,49752,497––% 6,1495,37777214.4%
79,02682,114(3,088)(3.8)%1,043,062648,198394,86460.9%
20232022%?
519,658233,072286,586123.0%?
264,314192,52271,79237.3%?
45,00541,5763,4298.2%?
44,16529,00815,15752.3%?
27,76419,7987,96640.2%?
25,52421,3964,12819.3%?
15,9958,4057,59090.3%
?
7,1198,946(1,827)(20.4)%
?
3,7254,577(852)(18.6)%
10,7676,7843,98358.7%964,036566,084397,95270.3%
?
2023
202363070.3%9.645.661??2023630
?
5.197123.0%2023630
?
3.6231.563
131.8%
?
CLLSLL2023630?
9,65037.6%2023630
?
6,080
814.4%CLLSLL2023630
?
2.6431.925
37.3%2023630
20236307,9002,0402023630
?
5,250
?20226308,2102,42020226305,250
?
202363020226301.3641.778
??
?2023
20236307.8634.297
2023630
75.9%81.6%
?????
202363020226307.6818.313
6,3208.2%20232022630
20232022%
258,219232,00926,21011.3%
23,27446,789(23,515)(50.3)%281,493278,7982,6951.0%549,855489,32460,53112.4%831,348768,12263,2268.2%
20236304,5902,330
2,270
?2023
2023630
?
BCL2(BGB-11417)
6,05012.4%5.499? 3,950? 1,200? 1,100
? 500
202363020226306.269,760
7.23515.6%
? 6,820
BRUKINSACLL? 1,890
?2023
? 1,990? 9402022630
202363020226302,1503,11096044.6%
20226301.17720236304,550
Leap Therapeutics
202363020226302,2102,52020236302022630
2023630(1)12
(2)16322(3)6,830
?2023
202212311.73220236302.993
72.8%
202212312.82320236303.21313.8%
202212312.16620236302.551
17.8%(i)(ii)
202212318.459202363010.319
22.0%
2023630202212312.6702.948
2023202263012313259,700290,284366,8572,570612701,3791148548
266,975294,781
?2023
202363020221231
202320226301231135,719184,775
91,108139,168
65,50651,806
38,48618,815
85,59141,817
38,54030,971454,950467,352202212314.67420236304.550
2.7%2023630
202212315.38120236306.28516.8%
2023630
?2023
202363020221231
2023202263012313,421,5743,875,037
105,693665,251628,478538,117BMS
20236307.296202263010202363078
201792023630
20211
6.5202112TIGIT20221
320237
?2023
20232022630
202320223,875,0374,382,887 (857,665)(616,522) 308,863869,103 146,212(28,847) (50,873)(71,212)
(453,463)152,5223,421,5744,535,409
20236308.5777.296
3.2942.013
20236304,550
20226306.16510
2.2061.6382022630
1.117
?
2023
Leap
20236303.0895.675
2.4711,16020226308.69110.510
1,1509,5407,500
20236301.4621,580
1.618
3,5206,66020226302,8801.154
6,7601,900
?
2023
20236307,1205,090
SEC20205SEC
?2023
2023630
53,22013,07440,146104,11563,82040,295628,478421,052207,426
46,16917,24628,923549,765126,688423,077
10,5572,6257,932
17,9905,95912,031
7,9862,6275,359381,187381,187–1,799,4671,034,278765,189
20236301.0414,030BMS6,380BMS
?2023
4.2112.074
12.5
2023630
5.498
20236301,060
2021620236301,800
2023630
20236303.812
?2023
7,5202022429
3.147
202363020221231
34391,120550
2023630
?2023
10020236304040
2023630202212312.9931.732
200520236304.9%20221231
8.2%
?2023
1994(PBOC)
2023630
20236302022123112.3%16.5%
2023630
7,5202022429
3.147
2023630
?2023
2023630
2023630
10,000202212319,000
20236307.53020226306.622
202363011.2202212315.5
1.833202212311.239
202363020221231
20236302022630
?2023
2023630XV
(a)XV78
(b)352(c)
(1)26,821,201
(2)
1.96%
9,545,000
(3)
0.70%
102,188
(4)
0.01%
7,727,927
(5)
0.56%
28,984,115
(6)
2.11%
510,941
(7)
0.04%
481,533
(8)
0.04%
1,456,052
(9)
0.11%
15,199,293
(10)
1.11%
172,372
(11)
0.01%
4,058,998
(12)
0.30%
1,127,542
(13)
0.08%
(14)
0.000004%
Margaret Han Dugan113,815
(15)
0.01%
Donald W. Glazer3,190,679
(16)
0.23%
Michael Goller453,232
(17)
0.03%
Anthony C. Hooper183,885
(18)
0.01%
Ranjeev Krishana453,232
(19)
0.03%
Thomas Malley1,365,980
(20)
0.10%
Alessandro Riva113,815
(21)
0.01%
Corazon (Corsee) D. Sanders136,500
(22)
0.01%
436,150
(23)
0.03%
?2023
(1) 20236301,371,420,1904,831,146,
(2) (1)1,292,260(2)24,849,647
(3)679,294
(3) Roth IRA PENSCO
(4) The John Oyler Legacy Trust
(5)
(6) Oyler Investment LLC
Oyler Investment LLC 99%
(7) The Oyler Family Legacy Trust
(8)(9)
(10) (1)5,362,972(2)9,667,965
(3)168,356(11)
(12) Wang Investment LLCWang Investment LLC99%(13)(14)
(15) (1)Dugan16,692(2)DuganDugan84,201(3) Dugan12,922
?2023
(16) (1)Glazer2,746,729(2)GlazerGlazer406,536(3)Glazer37,414
(17) (1)Goller33,774(2)GollerGoller406,536
(3)Goller12,922
(18) (1)HooperHooper146,471
(2)Hooper37,414
(19) (1)Krishana33,774(2)KrishanaKrishana406,536(3)Krishana12,922
(20) (1)Malley423,774(2)MalleyMalley929,284(3)Malley12,922
(21) (1)Riva16,692(2)RivaRiva84,201
(2)Riva12,922
(22) (1)Sanders16,978(2)SandersSanders106,600(3)Sanders12,922
(23) (1)16,692(2)406,536
(3)12,922
2023630
(a)XV7
(b)352(c)
?2023
2023630
XV23
(1)Amgen Inc.246,269,42617.96%Julian C. Baker
(2)
152,875,36311.15%Felix J. Baker
(2)
152,875,36311.15%Baker Bros. Advisors (GP) LLC
(2)
152,419,70311.11%Baker Bros. Advisors LP
(2)
152,419,70311.11%Baker Brothers LifeSciences Capital, L.P.
(2)
139,823,42310.20%HHLR Advisors, Ltd.
(3)
133,587,6559.74%HHLR Fund, L.P.
(3)
129,433,0599.44%The Capital Group Companies, Inc.
(4)
111,444,5298.13%JPMorgan Chase & Co.
(5)
13,309,8040.97%11,447,144(S)0.83%(S)
554,8460.04%2,328,7740.17%6,3830.0005%
85,312,9126.22%
(S)
(1) 20236301,371,420,1904,831,146
,
?2023
(2) Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLC
Baker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.
BBAMichael GollerRanjeev Krishana
BBABaker Brothers Life Sciences Capital, L.P.2021121520211215140,543,649Baker Brothers Life Sciences, L.P.Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBBA667, L.P.
11,152,058Baker Brothers Life Sciences, L.P.140,543,649723,996
BBABaker BrothersLife Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.140,543,649723,996
BBAJulian C. BakerFelix J. Baker270,868FBB3 LLC151,004
(3) (i)133,587,655HHLR Fund, L.P.YHG Investment, L.P.(ii)13,447,603Hillhouse BGNHoldings LimitedHHLR Adrisors, Ltd.YHG Investment, L.P.HHLR Fund, L.P.Hillhouse Capital Management, Ltd.Hillhouse Fund II, L.P.Hillhouse FundII, L.P.Hillhouse BGN Holdings LimitedHHLR Adrisors, Ltd.HHLR Fund,L.P.YHG Investment, L.P.133,587,655Hillhouse Capital Management, Ltd.
Hillhouse BGN Holdings Limited13,447,603HillhouseFund II, L.P.Hillhouse BGN Holdings Limited13,447,603
(4) (i)13,113,091Capital International, Inc.(ii)891,288Capital International Limited
(iii)1,865,765Capital International Sarl(iv)92,083,213Capital Research andManagement Company(v)238,182Capital Group Investment Management Private Limited
(vi)3,252,990Capital Group Private Client Services, Inc.Capital Group International, Inc.Capital Research and Management CompanyCapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.Capital Group International,Inc.Capital Bank and Trust CompanyThe Capital Group Companies, Inc.Capital Research and Management CompanyCapital Group International, Inc.CapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.19,361,316Capital Research and Management CompanyThe Capital Group Companies Inc.The Capital Group Companies Inc.Capital Research and Management Company
111,444,529
(5) JPMorgan Chase & Co.2023628
JPMorgan Chase & Co.101,512,71911,447,14485,312,9121,600,307117,964
2023630
XV23
?2023
2011201620182018202262220162018
20231120231
38,849,681
2.83%202331202383120182023831
1. 2011
20114152015417201120162220162011
2011
201143,560,4322016222016
201120231120112,643,0422011202311
2023630960,921202363020239151,681,9571,445,70820239150.1%2011
?2023
20112011
2011
2011
0.011.85
2011
20112016222016201120112018730
?2023
2011202363020112402011
2011520201613120231120236302011
2023
2023
201343
(1)
100.01879,267–879,255
(4)
12–2015629
(1)
100.50500,000–––500,000Thomas Malley2016125
(2)
101.85552,752–––552,752201343
(3)
100.0112–––12–2015629
(3)
100.5011–––112011520 2016131
(3)
100.01
1.85
663,694–81,666
(5)
–140581,8882011520 2016131
(3)
100.01
1.85
47,306––––47,306
2,643,042–960,921–1641,681,957
?2023
(1) 20%80%20%48(2)
(3) 20%/25%80%/75%20%/25%48/36
(4) 1317.81
(5) 1316.0120.25
0.011.85
2. 2016
20181172018127201620161142016
2016202041320206172016201657,200,0002016203020224172022622201620162016201666,300,000201617
2016
?2023
2016
20162022622
10%2016
30%202311201675,034,5042023112023630
38,849,68120162023630202391538,873,10638,739,9472016
2023112016189,114,8212016202311202363018,098,04120236302023915
171,016,949168,319,4492023915
12.21%2016
2016
1%
?
2023
(i)
1/13(ii)
20162016
20162030413201672016
202363020161,1192016201628202363020160.528.81
20231158,683,1442016202363064,070,1752016
?2023
(1)(2)
2023
2023
20161116
(3)
102.792.842,047,500––––2,047,5002017927
(3)
106.737.70935,000––––935,0002018430
(3)
1013.3713.04996,810––––996,8102018626
(3)
1012.7012.341,310,088––––1,310,088201965
(3)
109.259.232,193,282––––2,193,2822020617
(3)
1013.3313.421,821,976––––1,821,9762021616
(3)
1025.5426.53906,906–––906,9062022622
(3)
1011.7411.981,887,678––––1,887,6782023615
(3)
1016.0116.41–1,349,907–––1,349,90720161116
(3)
102.792.841,613,430––––1,613,4302017927
(3)
106.737.70750,000––––750,0002018626
(3)
1012.7012.34655,044––––655,044201965
(3)
109.259.23747,708––––747,7082020617
(3)
1013.3313.42560,599––––560,5992021616
(3)
1025.5426.53241,839––––241,8392022622
(3)
1011.7411.98471,913––––471,9132023615
(3)
1016.0116.41–327,249–––327,249
?2023
(1)(2)
2023
2023
Anthony C. Hooper*
202033
(5)
1012.6212.2221,970––––21,9702020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5426.5317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.4126,975–––26,975Margaret Han Dugan
2022228
(5)
1016.4716.2222,581––––22,5812022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975Donald W. Glazer
2017419
(4)
102.842.83199,992––––199,992201866
(5)
1015.7316.1517,442––––17,442201965
(5)
109.259.2364,610––––64,6102020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
2023
Michael Goller2017419
(4)
102.842.83199,992––––199,992201866
(5)
1015.7316.1517,442––––17,442201965
(5)
109.259.2364,610––––64,6102020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975Ranjeev Krishana
2017419
(4)
102.842.83199,992––––199,992201866
(5)
1015.7316.1517,442––––17,442201965
(5)
109.259.2364,610––––64,6102020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
2023
Thomas Malley201762
(5)
102.943.15169,988––––169,988201866
(5)
1015.7316.1517,442––––17,442201965
(5)
109.259.2364,610––––64,6102020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975Corazon D. Sanders
2020824
(5)
1018.5018.2627,482––––27,4822021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975Alessandro Riva2022228
(5)
1016.4716.2222,581––––22,5812022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,9752017419
(4)
102.842.83199,992––––199,992201866
(5)
1015.7316.1517,442––––17,442201965
(5)
109.259.2364,610––––64,6102020617
(5)
1013.3313.4245,383––––45,3832021616
(5)
1025.5425.6317,498––––17,4982022622
(5)
1011.7411.9834,645––––34,6452023615
(5)
1016.0116.41–26,975–––26,975
?2023
(1)(2)
2023
2023
2018430
(6)
1013.3713.04766,599––––766,599201965
(3)
109.259.23797,550––––797,5502020617
(3)
1013.4213.33756,821––––756,8212021616
(3)
1025.5425.63483,678––––483,6782022622
(3)
1011.7411.981,061,814––––1,061,8142023615
(3)
1016.0116.41–760,851–––760,8512020630
(3)
1014.5514.66104,754––––104,7542021616
(3)
1025.5426.53177,853––––177,8532022622
(3)
1011.7411.98589,888––––589,8882023615
(3)
1016.0116.41–409,058–––409,0582016713
(3)
102.272.29––––––2017627
(3)
103.503.49–––––2018626
(3)
1012.7012.34364,208––––364,208201965
(3)
109.259.23558,285––––558,2852020617
(3)
1013.3313.42525,564––––525,5642021616
(3)
1025.5426.53332,527––––332,5272022622
(3)
1011.7411.98707,876––––707,8762023615
(3)
1016.0116.41–507,234–––507,234Chan Lee
202285
(3)
102.262.27188,929––––188,9292023615
(3
1016.0116.41–248,950–––248,950
?2023
(1)(2)
2023
2023
2016713
(3)
102.272.29200,000–––200,0002016713
(3)
102.2720.892.293,046,805–32,500–123,014,2932016722
(3)
102.1319.142.1091,460–22,633––68,8272016722
(6)
102.1319.242.10786,608–37,050–27749,5312016729
(3)
102.112.0214––––14201689
(3)
102.042.10–––––2016822
(3)
102.282.24–––––201692
(3)
102.2619.302.27207,575–207,5714–2016912
(3)
102.332.42–––––2016919
(3)
102.512.38–––––2016926
(3)
102.352.27–––––20161012
(3)
102.482.426–––620161012
(6)
102.482.42–––––20161017
(3)
102.4216.322.5561,399–5,187–56,2122016111
(3)
102.562.57–––––2016117
(3)
102.432.46–––––2016118
(3)
102.462.51–––––20161116
(3)
102.792.84–––––20161121
(3)
102.462.42–––––
?2023
(1)(2)
2023
2023
20161128
(3)
102.492.38–––––20161130
(3)
102.432.441,274–––1,2742016121
(3)
102.442.37–––––2016129
(3)
102.072.0934,099–––34,099201713
(3)
102.342.397,800–––7,800201715
(3)
102.442.3963,661–––63,661201719
(3)
102.3718.682.43132,496–132,496––2017117
(3)
102.512.53–––––2017117
(6)
102.5118.782.5347,216–8,554–38,6622017123
(3)
102.462.49–––––2017130
(3)
102.802.62–––––201721
(3)
102.682.77144,989–––144,989201726
(3)
102.762.7632,201–––32,201201728
(3)
102.672.78–––––2017213
(3)
102.7718.522.7740,443–15,600–24,8432017227
(3)
102.972.93–––––201736
(3)
103.143.06–––––2017313
(3)
103.083.02116,701–––116,7012017320
(3)
103.0420.263.0484,968–9,100–75,868
?2023
(1)(2)
2023
2023
2017327
(3)
102.792.79–––––2017331
(6)
102.8118.382.8241,405–9,919–31,486201743
(3)
102.822.82–––––2017410
(3)
102.862.91–––––2017411
(3)
102.912.95–––––2017417
(3)
102.9216.732.9511,427–11,427––2017424
(3)
102.822.89–––––2017426
(3)
103.013.09–––––201751
(3)
103.1420.373.13260,663–260,663––201752
(6)
103.133.12104,689–––104,689201753
(3)
103.123.1211,999–––11,999201758
(3)
103.022.98–––––2017510
(3)
102.882.92–––––2017515
(3)
102.812.909,100–––9,1002017530
(3)
102.882.8821,060–––21,060201761
(6)
102.8318.932.941,093,690–77,285–1,016,4052017612
(3)
102.993.0012,727–––12,7272017614
(3)
103.0418.683.05583,895–98,098–485,7972017615
(6)
103.0519.033.043,144,284–189,644––2,954,640
?2023
(1)(2)
2023
2023
2017621
(3)
103.313.4517,784–––17,7842017623
(3)
103.413.45–––––2017627
(3)
103.5019.743.493,034,478–901,84952,132,6242017629
(3)
103.503.4543,654–––43,6542017710
(3)
105.4018.255.456,760–3,510–3,2502017717
(3)
105.674.19–––––2017717
(6)
105.6719.244.19292,825–46,995–245,8302017724
(3)
105.955.65–––––2017731
(3)
105.5819.455.4299,996–39,000–60,9962017731
(6)
105.5819.645.42336,271–23,608–312,663201781
(3)
105.4218.695.58156,000–117,000–39,000201782
(6)
105.585.45–––––201783
(3)
105.455.5119,994–––19,994201787
(3)
105.5620.355.9597,500–58,500–39,000201788
(3)
105.9514.866.0312,649–12,649––2017810
(3)
105.955.59–––––2017811
(3)
105.595.46–––––2017817
(3)
105.395.32–––––2017825
(3)
105.385.29–––––
?2023
(1)(2)
2023
2023
2017828
(3)
105.295.2824,167–––24,1672017831
(3)
105.305.30–––––2017831
(6)
105.3018.605.30180,596–6,578–174,018201795
(3)
105.7820.615.68269,997–234,988–35,0092017912
(3)
105.395.43–––––2017913
(3)
105.435.82–––––2017918
(3)
106.226.3722,269–––22,2692017922
(3)
106.5317.866.5568,588–68,588––2017925
(3)
106.556.56121,992–––121,9922017926
(3)
106.568.71–––––2017929
(3)
107.497.9637,492–––37,4922017111
(3)
107.1021.026.84226,356–1,300–225,05620171130
(3)
106.386.1510,764–––10,764201815
(3)
107.727.5819,071–––19,0712018131
(3)
109.5210.4480,017–––80,0172018228
(3)
1011.6120.9411.047,904–7,904––2018430
(3)
1013.3713.046,149–––6,149201866
(5)
1015.7316.1517,442–––17,4422018626
(3)
1012.7019.4512.34889,369–194,649–694,7202018629
(3)
1011.9011.8312,103–––12,1032018831
(3)
1013.6717.9513.6613,741–13,741––2018831
(7)
1013.6718.8913.66108,537–101,829–6,708
?2023
(1)(2)
2023
2023
2018928
(3)
1013.2813.2565,433–––65,4332018928
(8)
1013.2813.2539,260–––39,26020181130
(3)
1011.0711.7911,028–––11,02820181231
(3)
1010.5317.3410.79133,263–26,247–107,01620181231
(8)
1010.5310.7912,727–––12,7272019125
(3)
109.6210.4438,649–––38,6492019228
(3)
1010.7718.5410.5415,600–15,600––201935
(3)
1011.6811.5178,494–––78,4942019510
(3)
109.3310.3244,213–––44,213201965
(3)
109.2518.659.232,394,600–351,50711,5442,031,549201965
(5)
109.259.23129,220–––129,2202019628
(3)
109.679.53–––––2019830
(3)
1011.1420.0011.0697,201–17,901–79,30020191129
(3)
1015.7115.83–––––20191231
(3)
1012.8017.6012.9215,834–15,834––202033
(3)
1012.6212.19–––––2020331
(3)
109.659.67294,775–––294,7752020512
(3)
1012.5612.18–––––2020529
(3)
1012.4912.73–––––2020617
(3)
1013.3319.1313.421,543,243–278,91512,1941,252,1342020617
(5)
1013.3313.4290,776–90,766–90,7662020630
(3)
1014.5514.66212,771–––212,771
?2023
(1)(2)
2023
2023
202087
(3)
1017.2416.9940,248–––40,2482020831
(3)
1018.6918.85––––––2020930
(3)
1021.6522.038,021–––8,0212020116
(3)
1023.0823.07175,708–––175,70820201130
(3)
1021.9920.9915,756––––15,7562021122
(3)
1027.4628.8155,263–––55,2632021226
(3)
1025.3625.816,331–––6,3312021331
(3)
1025.6126.78148,824–––148,824202157
(3)
1024.1524.7884,240–––84,2402021528
(3)
1027.0027.58121,485–––121,4852021616
(3)
1025.5426.531,878,695––20,397144,3911,713,9072021630
(3)
1027.4827.2859,397–––59,397202186
(3)
1025.8425.61150,423––4,251146,1722021831
(3)
1023.2223.72153,322–––153,3222021930
(3)
1027.8128.7357,018–––1,56055,4582021115
(3)
1028.3828.0845,786–––22,55523,23120211130
(3)
1026.4026.8564,649–––64,64920211231
(3)
1021.0320.8459,332––12,36346,9692022127
(3)
1017.2718.61371,059–––371,0592022228
(3)
1016.4718.8116.22171,626–3,83512,1684,043151,5802022331
(3)
1015.8515.46135,694–––135,694202256
(3)
1012.2712.5080,821–––80,8212022531
(3)
1010.3010.56123,604–––123,604
?
2023
(1)(2)
2023
2023
2022622
(3)
1011.7413.6911.985,816,690–2,028101,8335,712,8292022622
(9)
1011.7411.9811,804–––11,8042022630
(3)
1012.4812.8177,974–––77,9742022831
(3)
1012.7313.3222,009–––22,0092022930
(3)
1010.4810.5866,690–––66,69020221110
(3)
1013.5614.5254,106–––54,10620221130
(3)
1013.8414.7417,745–––17,74520221230
(3)
1017.2217.267,592–––7,5922023125
(3)
1020.5220.64–29,471––29,4712023228
(3)
1016.6217.28–61,724––61,7242023331
(3)
1016.6716.99–63,765––63,765202355
(3)
1020.0520.06–31,837––31,8372023531
(3)
1017.5617.98–19,188––19,1882023615
(3)
1016.0116.41–5,314,374––5,314,3742023630
(3)
1013.7413.82–30,277––30,277
58,683,1449,396,6603,662,282170,508176,83964,070,175
* Anthony C. Hooper2023417
(1) 13
(2) 13
?2023
(3) 25%
75%25%36(4)(5)
(6) 20%80%20%48
(7) 48(8)
(9) 50%50%50%12
2016
(3)
1,349,9072023615(1)16.41–16.0110,999,987327,2492023615(1)16.41–16.012,666,654Anthony C. Hooper26,9752023615(2)16.41–16.01199,963Margaret Han Dugan26,9752023615(2)16.41–16.01199,963Donald W. Glazer26,9752023615(2)16.41–16.01199,963Michael Goller26,9752023615(2)16.41–16.01199,963Ranjeev Krishana26,9752023615(2)16.41–16.01199,963Thomas Malley26,9752023615(2)16.41–16.01199,963Corazon D. Sanders26,9752023615(2)16.41–16.01199,963Alessandro Riva26,9752023615(2)16.41–16.01199,963
26,9752023615(2)16.41–16.01199,963
?2023
(3)
760,8512023615(1)16.41–16.016,199,947409,0582023615(1)16.41–16.013,333,291507,2342023615(1)16.41–16.014,133,298Chan Lee248,9502023615(1)16.41–16.012,028,619
5,550,6362023125
2023630
(1)13.82
20.64
–13.74
20.52
45,464,808
9,396,66080,105,854
(1) 25%
75%25%36
(2)
(3)
?2023
20162023630201614,39320162017926202363020231155,397,17320162023630201668,073,668
2023
2023
2023(1)
2018430(6)13.37––––––2018626(6)12.70––––––2021616(6)25.54109,694–36,556–73,13815.462022622(6)11.74334,009–83,499–250,51014.282023615(6)16.01–355,641––355,641–2018626(6)12.70––––––2021616(6)25.5429,250–9,750–19,50015.462022622(6)11.7483,499–20,865–62,63414.282023615(6)16.01–86,216––86,216–Anthony C. Hooper2021616(7)25.547,800–––7,800–
2022622(7)11.7416,692–––16,692–2023615(7)16.01–12,922––12,922–Margaret Han Dugan2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–Donald W. Glazer2021616(7)25.547,800–––7,800–
2022622(7)11.7416,692–––16,692–
2023615(7)16.01–12,922––12,922–
?2023
2023
2023
2023(1)Michael Goller2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.012023615(7)16.01–12,922––12,922–Ranjeev Krishana2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.012023615(7)16.01–12,922––12,922–Thomas Malley2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.012023615(7)16.01–12,922––12,922–Corazon D. Sanders2021616(7)25.54––––––
2022622(7)11.7416,692–16,692––16.012023615(7)16.01–12,922––12,922–Alessandro Riva2022622(7)11.7416,692–16,692––16.01
2023615(7)16.01–12,922––12,922–2021616(7)25.54––––––2022622(7)11.7416,692–16,692––16.012023615(7)16.01–12,922––12,922–
2018430(6)13.37230,009–230,009––19.61201965(6)9.25108,368–108,368––17.492020617(6)13.3367,093–33,527–33,56615.402021616(6)25.5458,500–19,500–39,00015.462022622(6)11.74187,876–46,969–140,90714.282023615(6)
16.01–200,447––200,447–
?2023
2023
2023
2023
(1)2020630(6)14.5527,612–13,793–13,81913.742021616(6)25.5421,515–7,163–14,35215.462022228(6)16.4761,750–15,431–46,31916.622022622(6)11.74104,377–26,091–78,28614.282023615(6)16.01–107,770––107,770–2018626(6)12.70––––––201965(6)9.2518,993–18,993––17.492020617(6)13.3346,592–23,283–23,30915.402021616(6)25.5440,222–13,403–26,81915.462022622(6)11.74125,255–31,304–93,95114.282023615(6)16.01–133,627––133,627–Chan Lee
2022729(6)13.45116,012–––116,012–2023615(6)16.01–65,585––65,585–2018131 20211231
(6)18.5518,205,967–6,300,684806,75411,098,529(2)202211 20221231
(6)12.46–37,617,8532,9382,276,46935,338,446(3)202311 2023630
(6)15.69–28,387,437–161,04428,226,393–201924 20211231
(6)12.018,684–8,684––(4)202211 20221231
(8)17.7023,634–––23,634–
55,397,17329,453,02114,435,7592,340,76768,073,668
?2023
(1) 13
(2) 1310.1016.92
(3) 1316.92
(4) 1310.1016.92
(5) 1316.92
(6) 25%
(7)(8)
?2023
(3)355,6412023615(1)–16.015,499,85186,2162023615(1)–16.011,333,297Anthony C. Hooper12,9222023615(2)–16.01199,834Margaret Han Dugan12,9222023615(2)–16.01199,834Donald W. Glazer12,9222023615(2)–16.01199,834Michael Goller12,9222023615(2)–16.01199,834Renjeev Krishana12,9222023615(2)–16.01199,834Thomas Malley12,9222023615(2)–16.01199,834Corazon D. Sanders12,9222023615(2)–16.01199,834Alessandro Riva12,9222023615(2)–16.01199,834
12,9222023615(2)–16.01199,834200,4472023615(1)–16.013,099,836107,7702023615(1)–16.011,666,622Chan Lee65,5852023615(1)–16.011,014,247
133,6272023615(1)–16.012,066,490
28,387,437202311
2023630
(1)–15.69445,528,243
29,453,021482,348,341
(1) 25%
(2)
?2023
(3)
3. 2018
20181172018127201820186620182019652018
202162018
202191
2018201815%20182018
201820185%2018
1%10%25,000
?2023
31912018
85%2018
2018
?2023
20187,355,31520231120183,666,071202311
202291930,8522018202363020239152,735,2191,941,0752018
20236302023630202331
20187,355,3152023112018
3,666,071202291930,8522018202363020239152,735,2191,941,0752023915
0.14%2018
20182018201812720185.5
?2023
20182022912023313,0393,21820182018
202291
202291
(1)(2)
202291611.1910,626.7610,617
11.19
202291611.1910,403,11910,403,119
11.19
929,90310,413,732
?2023
1. 20229113.20103.60
12,251,44496,153,7432022912018
2. 202291
2018202322811.19930,8522023228
17.28135.5816,084,407126,195,362
3. 20229110,413,736
930,852
4. 2018
4. 2018
201866201812,000,0002018
202262220162018
201817
2018
?2023
5635(c)(4)2018
20182022622
20226222018
20231120182023630
20182018202262220236302018202363020239150
020239150%2018
2018
2018
2022622201620182018
2018
1%
?
2023
(i)
1/13(ii)
2018
?2023
2018
(1)(2)
2023
2023
2018831
(3)
1013.6713.66–––––
–––––
(1) 13
(2) 13
(3) 25%
75%25%36
?2023
C.2.1
Ranjeev Krishana
?2023
3.21D.3.3D.3.7
AnthonyC. Hooper2023417Thomas MalleyCorazon (Corsee) D.Sanders2023913Anthony C. HooperThomasMalley
3.25E.1.2
MargaretHan DuganRanjeev KrishanaMargaret Han Dugan
B.3.1
Donald W. GlazerMichael GollerAnthony C. Hooper2023417Alessandro RivaDonald W. Glazer
?2023
B.8
202311
13.51(B)(1)
13.51(B)(1)
Anthony C. Hooper2023417
20239142023913Anthony C. HooperThomas MalleyThomas Malley
?2023
202012
174.8515,895,001206,635,013
20.5%2,779,241,000(a)201910303036%(b)1.007.8420191031
26%(c)2019103126%
201911292023630
20221231
2023
2023
(%)(a)
2,779,241100%2,080,0682,186,658592,583
(a) 12.5
20191129
202620191112019129202013
?2023
2020924
20.6%
20.4%
75,000,000
2020121(a)20%(b)60(c)
20203182020925202010
20219165,5292,151,87750,000,0002022123150,000,0002023
2021121520216162021
192.60
234.89391.68115,055,260
3,392,616,000(i)(ii)(iii)(iv)(v)
?2023
202011162021129202142020215142021612021621202162820216302021792021728202110152021111620211123202111242021112920211130202112220211262021127202112132021122120211228202242920226272022830202292820234252021430
2023630109107
2023630
20221231
2023
2023
13,245,9404,499,8495,859,1207,386,820467,700376,601405,82161,879150,000153,451153,451(3,451)*136,36071,58080,18056,1806,000,0002,662,6743,957,1922,042,8081,630,155489,000489,0001,141,15521,630,1558,253,15510,944,76410,685,391
*
2023630
?
2023
2023202263020232022630
3000
3000()(i) 2525
20236302023
(ii) 252023630
(iii) 25
3000()
(i) 25
?
2023
(ii) 252023630
(iii) 25
Thomas MalleyAnthony C.Hooper2023417Corazon (Corsee) D. SandersThomasMalley2023913Anthony C. HooperThomas Malley
2023630
2023630
13.2013.2113.22
2023825
?2023
20232022
14964,036566,084 479,02682,114 1,043,062648,198 177,779136,410 831,348768,122 723,533625,976 375376 1,733,0351,530,884
(689,973)(882,686) 31,08621,502 (45,515)(117,650)
(704,402)(978,834)1025,16622,090
(729,568)(1,000,924)
(0.54)(0.75)1,357,211,3081,334,252,648 (6.99)(9.75)
104,400,870102,634,819
?2023
20232022(729,568)(1,000,924) (73,172)(88,085) 6,902(12,315)
(795,838)(1,101,324)
?2023
202320226301231
3,410,3683,869,564 59,693196 5105,693665,251 6299,282173,168 7321,333282,346 11255,050216,553
4,401,4195,207,078 51,5135,277 81,031,938845,946 99,422109,960 946,89540,616 11147,549170,413
1,327,3171,172,212
5,728,7366,379,290
12266,975294,781 11454,950467,352 4159,034213,861 1017,07425,189 23,50824,041 462,516114,335 13421,052328,969
1,405,1091,468,528
?2023
202320226301231
13207,426209,148 424,27642,026 25,82134,517 1015,65215,996 4208,775179,625 1143,11846,095
525,068527,4071,930,1771,995,935
0.0001 9,500,000,00020236302022 1231 1,376,251,3361,356,140,180137135 11,752,01911,540,979 18(143,687)(77,417) (7,809,910)(7,080,342)
3,798,5594,383,3555,728,7366,379,290
?2023
202212311,356,140,18013511,540,979(77,417)(7,080,342)4,383,355 121,342–––––
19,989,814232,347––32,349 ––178,693––178,693 –––(66,270)–(66,270) ––––(729,568)(729,568)20236301,376,251,33613711,752,019(143,687)(7,809,910)3,798,559202112311,334,804,28113311,191,00717,950(5,076,527)6,132,563 ––(152)––(152) 2,165,904–––––
12,669,239118,971––18,972 ––146,860––146,860 –––(100,400)–(100,400) ––––(1,000,924)(1,000,924)20226301,349,639,42413411,356,686(82,450)(6,077,451)5,196,919
?2023
20232022
(729,568)(1,000,924) 42,34632,061 17178,693146,860 52,17823,529 4(22,669)(45,583) (15)555 7676,360 (131,923)307,430 (53,598)(31,633) (30,627)32,335 (32,678)(30,362) (8,082)21,168 (72,577)(76,737) 88(1,581)
(857,665)(616,522) (247,055)(95,421) (11,582)(11,504) 567,5001,051,028 –(75,000)
308,863869,103
?2023
20232022
1315,771– 13161,84667,586 13(66,574)(115,405) 35,16918,972
146,212(28,847)(50,873)(71,212)(453,463)152,5223,875,0374,382,8873,421,5744,535,409 3,410,3684,531,137 9,693333 1,5133,939 32,52924,436 10,01512,899 95,40458,676
?2023
1.
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PD-1
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1204521,000353
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?2023
1.
202363057
BeiGene 101–100%BeiGene AUS Pty LtdBeiGene Australia
56,947,230100%BeiGene Austria GmbH35,000100%
*
1,922,787,023
100%
*
14,540,000,000
100%BeiGene (Canada) ULC100100%BeiGene Colombia S.A.S.–100%BeiGene ESP, S.L.U.3,000100%BeiGene France Sarl7,500100%
*
12,490,389,800
100%
*263,000,000100%BeiGene Germany GmbH25,000100%
?2023
BeiGene (Hong Kong) Co., Limited
13,700,000,000
100%
*4,000,000100%BeiGene International GmbH20,000100%BeiGene (Italy) S.r.l.10,000100%BeiGene Brasil Ltda.2,450,190100%BeiGene Malaysia Sdn. Bhd.–100%BeiGene Poland sp. z o.o.5,000100%BeiGene South Africa Pty Ltd.–100%BeiGene Sweden AB25,000100%BeiGene Turkey Medical Products Trade Limited Company
10,000100%BeiGene Ireland Limited BeiGene Ireland
–100%BeiGene Japan, Ltd.1,781,660100%
1.
?
2023
BeiGene Korea Y.H.145,000,000100%BeiGene Netherlands B.V.–100%BeiGene NZ Unlimited100,000100%BeiGene Pharmaceuticals GmbH20,000100%
*
3,800,000
100%BeiGene Pharmaceuticals Israel Ltd.10,000100%
*
7,000,000
100%
*1,000,000100%BeiGene Shanghai–100%BeiGene Shanghai 101–100%BeiGene Shanghai Asset Limited–100%
*
1,434,344,311
100%
*–100%
1.
?2023
*
1,000,000
100%*
270,000,000
100%BeiGene Singapore Pte. Ltd.1100%
*
3,673,218,389
100%BeiGene Switzerland GmbH BeiGene Switzerland
20,000100%168,000,000100%BeiGene (Thailand) Ltd.5,000,000100%BeiGene UK, Ltd.BeiGene UK23,956,065100%BeiGene United Kingdom, Ltd.110100%BeiGene USA, Inc.BeiGene USA1100%BeiGene US Holdings, LLC318,100,000100%BeiGene US Manufacturing Co., Inc.474,100,000100%
1.
?2023
BeiGene Hopewell Urban Renewal, LLC399,943,128100%Pi Health Aus Pty Ltd–100%Pi Health, Ltd.30,500,000100%Pi Health USA, LLC8,500,000100%Pi Health Brasil Consultoria Ltda.1,299,275100%Pi Health Hong Kong Limited–100%B10 Health Technologies Private Limited
370,344,475100%Newco 101–100%*
1.
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1.
2023630202320226302023202263020232022630
10-QS-X10
2022123110-K
2023630
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2023
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20222022102022930
9910820229302022630
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?2023
1.
202332023-01842
36020231215(1)(2)
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20221231
2023630
?2023
2.
20226301
2022630
26,889(4,799)22,090(1,005,723)4,799(1,000,924)
(0.75)–(0.75)(9.80)0.05(9.75)
2022630
(1,005,723)4,799(1,000,924)(1,106,123)4,799(1,101,324)
2022630
(1,005,723)4,799(1,000,924)7,550(6,995)555
32,3152032,335
19,5251,64321,168
(2,114)533(1,581)(616,522)–(616,522)
?2023
2.
20211231(4,966,103)(110,424)(5,076,527)6,242,987(110,424)6,132,563
(1,005,723)4,799(1,000,924)(1,005,723)4,799(1,000,924)2022630(5,971,826)(105,625)(6,077,451)5,302,544(105,625)5,196,9193.
?2023
3.
202363020221231
2023630123
847,781––
105,693––
––5,190
2,3001,077– ––3,000
955,7741,0778,190
20221231123
758,114––
662,251––
––5,190
3,307706– ––3,000
1,426,6727068,190
?2023
3.
Leap Therapeutics, Inc.Leap2020120219LeapLeap1Leap2
202363020221231
?2023
4.
20232022630
20232022630
2023202220,38024,24052,49752,4976,1495,37779,02682,114
20211
?2023
4.
650,000,0001,300,000,000250,000,000
(1)(2)(3)
?2023
4.
650,000,000
1,231,000,000420,000,000484,646,000
165,354,00020216302021630
202363016,796,000202263020,656,00020236305,013,000
20226305,377,000
?2023
4.
202112
TIGIT
?????
2022
20221300,000,000202320232023600,000,000700,000,000
745,000,0001,150,000,000
50%25%
(1)
(2)(3)
(4)
?2023
4.
300,000,000
(i)(ii)
71,980,000213,450,00014,570,000
?2023
4.
202363052,497,000
202263052,497,000
20236303,583,00020226303,584,00020236302,636,00020237
201910
???202012
?
2023
4.
???
?
(XGEVA
?
)2019202011
20207
?202012?
B(ALL)20217?
(R/R)2022
?
CD19B
1,250,000,000KRAS G12CLUMAKRAS
?
(sotorasib)LUMAKRAS2022420
LUMAKRAS20232(i)2023112023831
LUMAKRAS(ii)LUMAKRAS
?2023
4.
808100%
201910202012174.8515,895,001
20.5%
Anthony Hooper2020120231
132.74
2,109,902,000
601,857,0002,779,241,0002,162,407,000616,834,000
?2023
4.
20232022630
2023202223,27446,78922,66945,58345,94392,372
2023
549,765202363020221231
202320226301231
62,516114,335208,775179,625271,291293,960
?2023
4.
20232022630
202320221,1843,4781,311898(29,388)(26,642)(26,893)(22,266)202363039,277,000202263030,061,00020236302022123111,069,00054,064,0005.
20236302022123111,206,0005,473,000
?2023
5.
2023630
107,802–2,109105,693107,802–2,109105,69320221231
674,262–9,011665,251674,262–9,011665,25120236302023630
?2023
5.
Leap Therapeutics, Inc. (Leap)20201Leap5,000,000Leap BB20203LeapLeap20219Leap7,250,000
Leap2023630Leap
6.2%Leap
9.8%
2023630636,000202263022,661,000202363020221231
202320226301231Leap2,3003,307Leap1,077706
20236302022123159,209,000
57,054,00020236301,081,0002022630366,000
?2023
5.
20236302022123130,020,00027,710,000
20236302,624,00020226301,234,0006.
202320226301231299,668173,379
(386)(211)
299,282173,16830120
20232022
63012316299,180172,633612102535
299,282173,168
?2023
6.
20232022630
20232022211415234(210)
(43)–
(16)3
386208
7.
202320226301231109,04888,957
31,47220,886180,813172,503321,333282,346
?2023
8.
202320226301231
65,48565,485214,080222,448172,844175,679170,424158,908
53,36653,786
72,83947,483749,038723,789(201,406)(171,470)
484,306293,6271,031,938845,94620211175,197,00042
2023630314,707,0002023202263040,332,00030,041,000
?2023
9.
202363020221231
202363020221231
7,500(4,375)3,1257,500(4,000)3,500 49,388(5,618)43,77041,235(4,119)37,116 816(816)–816(816)–
57,704(10,809)46,89549,551(8,935)40,616BMS
2018920202
20242
?2023
9.
202320221,6391,6443753762,0142,0202023630123120231,8573752,23220243,7147504,46420253,7147504,46420263,7147504,46420273,7145004,214202827,057–27,057
43,7703,12546,895
?2023
10.
202363025,166,000202263022,090,00020232022630
2023630202363012,524,00012
2023630969,000
202363020221231
20236302013202320132023
2018202320152023
20122023
?2023
11.
202320226301231
72,39171,488
69,31958,950
18,48520,478
36,86622,7771,9923,0397,5933,6647,1981,510
41,20634,647255,050216,553
202320226301231109109
13,14022,025(1)
30,53948,642
1,7348046,4207,054
95,60791,779147,549170,413
(1)
?2023
11.
202320226301231135,719184,77591,108139,16865,50651,80638,48618,81585,59141,81738,54030,971454,950467,352
202320226301231
34,86538,1767,9967,760257159
43,11846,095
?
2023
12.
2023202263012313259,700290,284366,8572,570612701,3791148548
266,975294,781
?2023
13.
202363020221231
202363020221231201844580,0009202744(1)10,34375,0007,25050,0002020122(2)92029120(2)5,02436,4291,45010,0002020119378,00092029118(3)5,51640,0005,43737,5002020924200,000(4)4.3%150,0001,087,666150,0001,034,554202222550,000120232252.2%––50,000344,851202365400,00012024643.2%55,164400,000––202354340,00012024534.7%46,889340,000––2023530200,000120245292.8%27,582200,000––
(5)120,534874,000114,832792,000
421,0523,053,095328,9692,268,905201844580,0009202744(1)64,818470,00075,395520,0002020122(2)92029120(2)41,176298,57147,847330,0002020119378,00092029118(3)44,200320,50049,369340,5002022729480,000102032728(6)57,232415,00036,537252,000
207,4261,504,071209,1481,442,500
?2023
13.
1. 20236304.5%
20236303,483,00025,000,000
2. 2020122
1,100,000,000
202012311,100,000,000350,000,00020236
304.1%2023630731,0005,000,000
201733
3. 20236304.0%
20236302,518,00017,500,000
4. 20209200,000,000120,000,00080,000,000
2021108202110820221082022930
20231092017125
5. 202220211231
875,000,0002022121520239182023630
16,574,000117,000,00028,174,000199,000,00020236302.6%
6. 20227
480,000,000202363022,502,000163,000,00020236304.1%
?2023
13.
20236309,465,000772,000202263010,984,0001,935,000
14.
??????
BMS
???
20232022630
202320221,176,933638,273(212,897)(72,189)964,036566,08420232022630
20232022?
519,658233,072?
264,314192,522
?
45,00541,576?
44,16529,008
?
27,76419,798?
25,52421,396
?
15,9958,405
?
7,1198,946
?
3,7254,577
10,7676,784964,036566,084
?2023
14.
20232022630
2023202241,81759,639212,89772,189(169,123)(60,316)
85,59171,512
15.
20232022177,779136,410840,33230,041
831,348768,122
13,42913,36692,0142,020 542,029489,416 178,717146,860 32,30225,966
753,048662,242
68,911118,3556234(210)
(40,584)(32,520)
(67)73
20232022630344,713,000293,291,000
?2023
16.
20232022
(729,568)(1,000,924) 1,357,211,3081,334,252,64820232022630
17.
2016
20161(IPO)
201620162016265,029,595201620112011
2016201120236302011
20165,166,822201812201638,553,159
20206201657,200,000
20304132016
?2023
17.
2016202363020169,396,66029,453,021
2023630201664,070,17568,073,6682023630201638,873,106
20162016
201666,300,00020223315%20226222018201862018201812,000,000
5635(c)(4)5635(c)(4)20182018
201620188
201820236302018201620182022622
?2023
17.
20182018620183,500,000201812
3,855,3157,355,3152019620216
202191
15%
10%20236302,735,219
2023228930,582171.1013.16145.4411.1910,4142022831861,315171.6613.20145.9111.229,6672022228667,160210.5216.19178.9413.769,183
?2023
17.
20232022630
2023202279,97667,96598,74178,895178,717146,86018.
20221231(62,523)(9,011)(5,883)(77,417)
(73,172)6,902–(66,270)(73,172)6,902–(66,270)2023630(135,695)(2,109)(5,883)(143,687)
?2023
19.
20191031201912620209242023130(SPA)20219165,5292,151,87750,000,000
202112
192.60391.68115,055,2603,392,616,000
20.
10%50%
?2023
20.
10%
2023630202212313,305,583,0003,548,881,00021.
2023630104,115,00040,295,00063,820,000BMS
BMS
2023630381,187,000
1,250,000,0002023630
549,765,000
20216
202363017,990,000
?2023
21.
15,057,000202363010,557,000
20236302,627,000
?2023
22.(a) 20232022630
20232022630(i)50,000202250,000(ii)75,000202275,000(iii)
2,017,00020222,141,000(b)
202320222,9143,423323719,85719,62622,80323,086
?2023
23.
20232022540,828403,164362,307156,26960,9016,651964,036566,084
202320222,636–
54,52357,480
21,86724,634
79,02682,114
?2023
24.
2023728
(i)(ii)(iii)
(iv)
202381BMS-Celgene
ABRAXANE20172018BMS-Celgene
201723,273,10820231231
??
20241231
?2023
25.
2023630
(i)(iii)(iv)(831,348)(13,557)–830(844,075)(723,533)(13,107)–650(735,990)
31,086––(1,556)29,530(704,402)(26,664)–(76)(731,142)(25,166)(1,567)7,376–(19,357)(729,568)(28,231)7,376(76)(750,499)
?2023
25.
2022630
(i)(768,122)(5,520)(773,642)(625,976)(4,044)(630,020)(978,834)(9,564)(988,398)
(22,090)(15,102)(37,192)(1,000,924)(24,666)(1,025,590)
?2023
25.
2023630
(i)(ii)(iii)(iv)99,422–––(2,381)97,041255,050––7,376–262,4265,728,736––7,376(2,381)5,733,73111,752,01928,231–––12,296,186
208,042*307,894*––(7,809,910)(28,231)–7,376(76)(8,349,082)
(208,042)*(307,894)*–(2,305)*3,798,559––7,376(2,381)3,803,554
?2023
25.
20221231
(i)(ii)(iv)109,960––(2,305)107,6556,379,290––(2,305)6,376,98511,540,97933,993––12,056,915
174,049*307,894*–(7,080,342)(33,993)–(2,305)(7,598,583)
10,311––
(184,360)*(307,894)*–4,383,355––(2,305)4,381,050*
(i)
202363026,664,00020226309,564,000
?2023
25.
(ii)
20162307,894,000
307,894,000(iii)
20226302023630
?
2023
25.
(iv)
201911
20226302023630(v)
(ASC820)
20236302023630
26.
20236302022630
?2023
201120114152015417
2011201620161142016
2022
201820182021616
2021912018 2018
201866201887
20182022622ADS13
198747
20191031202012
20191031
20101028
2017125201733
?2023
BeiGene Switzerland GmbH201791
FDA(U.S. Food and Drug Administration)
19981127
?2023
NMPA(National Medical Products
Administration)Novartis Pharm AG
20187302023630
?2023
?2023
BRAFB-rafBTKBCLL
PARPADP
DNADNAPD-11Tpro-B
PD-L1PD-L2PD-1T
RAFRAFBRAF-BRAF
BRAF-CRAFCRAF-CRAFSLLsNDA
?2023
TTT
BTIM-3T3Th1