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华东医药:2021年第三季度报告(英文版) 下载公告
公告日期:2021-11-10

Stock code: 000963 Stock abbreviation: Huadong Medicine Announcement No.: 2021-076

Huadong Medicine Co., Ltd.The Third Quarterly Report 2021

Important Declaration:

1.The Board of Directors, Board of Supervisors, directors, supervisors and senior management ofHuadong Medicine Co., Ltd. (hereinafter referred to as the “Company”) hereby guarantee that theinformation presented in this report is authentic, accurate and complete and free of any false records,misleading statements or material omissions, and shall undertake individual and joint legalliabilities.

2.The Company’s legal representative and the officer in charge of accounting, and head ofaccounting department (accounting supervisor) hereby declare and guarantee that the financialstatements in this quarter report are authentic, accurate and complete.

3.Has the third quarterly report been audited?

□ Yes √ No

This report is prepared both in Chinese and English. Should there be any discrepancy between theChinese and English versions, the Chinese version shall prevail.I. Key financial data(I) Key Accounting Data and Financial IndicatorsWhether the Company needs to perform retroactive adjustment or restatement of previous accounting data

□ Yes √ No

The Company and all members of the Board of Directors hereby guarantee that the informationpresented in this report is authentic, accurate and complete and free of any false records,misleading statements or material omissions.

The current reporting periodChange of the current reporting period over the same period last yearFrom the beginning of the year to the end of the reporting periodChange from the beginning of the year to the end of the reporting period over the same period last year
Operating revenue (yuan)8,748,039,460.66-1.04%25,927,477,363.271.67%
Net profit attributable to shareholders of listed companies (yuan)595,038,254.49-9.88%1,895,384,579.34-20.74%
Net profit attributable to shareholders of listed568,039,187.19-9.00%1,762,020,074.37-13.24%
companies after deducting non-recurring gains/losses (yuan)
Net cash flow from operating activities (yuan)————2,105,916,826.7210.73%
Basic earnings per share (yuan/share)0.3401-9.88%1.0832-20.74%
Diluted earnings per share (yuan/share)0.3401-9.88%1.0832-20.74%
Weighted average return on equity (ROE)3.75%-1.00%12.28%-5.41%
End of the current reporting periodEnd of last yearChange of the end of the current reporting period over the end of last year
Total assets (yuan)27,687,711,922.8124,201,348,154.7514.41%
Owners’ equity attributable to shareholders of listed companies (yuan)16,250,585,502.8814,619,821,308.6011.15%

Share capital of the Company as of the trading day before disclosure:

Share capital of the Company as of the trading day before disclosure (share)1,749,809,548

Fully diluted earnings per share calculated on the basis of the latest Share capital

Dividends paid on preferred shares0.00
Perpetual bond interest paid (yuan)0.00
Fully diluted earnings per share calculated on the basis of the latest Share capital (yuan/share)1.0832

(II)Items and amounts of non-recurring gains/losses

√ Applicable □ N/A

ItemAmount of the current reporting periodAmount (from the beginning of the year to the end of the reporting period)Note
Gains/losses on disposal of non-current assets (including the written-off part of the accrued assets impairment reserve)-356,832.47-466,951.55
Government grants included in current gains/losses(excluding those closely related to normal operating activities, in line with national policies and measured according to unified national standards)19,665,596.43157,973,691.62
Receivables subject to separate impairment test and reversal of reserve for impairment5,388,185.00
Other non-operating income or expenditure2,888,378.89-2,028,188.08
Less: Amount affected by income tax-2,745,429.3819,349,865.15
Amount affected by minority interest (after tax)-2,056,495.078,152,366.87
Total26,999,067.30133,364,504.97--

Details of other gains/losses items satisfying the definition of non-recurring gains/losses:

□ Applicable √ N/A

No such case.If the Company recognizes a non-recurring gain/loss listed in the “Interpretative Announcement No. 1 on Information DisclosureCriteria for Public Companies – Non-Recurring Profit/Loss” as a recurring gain/loss, reasons should be specified.

□ Applicable √ N/A

No such case.

(III)Changes in key accounting data and financial indicators and their reasons

√ Applicable □ N/A

Unit: RMB yuan
Balance sheet itemEnd of the periodBeginning of the periodChange rateNotes on cause of changes
Accounts receivable financing572,080,968.64828,659,217.25-30.96%Mainly due to banker’s acceptance discount in the current period
Accounts receivable8,147,812,875.636,137,675,568.8232.75%Mainly due to income growth and capital return fluctuation
Other receivables299,688,469.5487,269,489.82243.41%Mainly due to the increase of equity transfer accounts receivable and suspense accounts receivable
Other current assets38,039,156.5285,654,691.58-55.59%Mainly due to the decrease of input VAT to be deducted at the end of the period
Other equity instruments investment129,841,291.42225,453,120.05-42.41%Mainly due to the transfer of equity instrument investment of Ningbo Donghai Bank and the sale of some RAPT shares in the current period
Goodwill2,100,106,651.091,469,617,262.1042.90%Mainly due to the acquisition of Doer Biologics and High Tech in the current period
Notes payable1,381,336,643.84554,336,058.71149.19%Mainly due to the increase of bill payment in the current period
Contract liabilities186,487,690.0294,384,629.7797.58%Mainly due to the increase of advance drug payments in the current period
Non-current liabilities due within one year23,288,386.1167,813,886.68-65.66%Mainly due to the decrease of long-term payables and long-term borrowing due within one year
Long-term payables164,454,591.4826,812,354.90513.35%Mainly due to the increase in contingent and deferred consideration resulting from the acquisition of external companies by the subsidiaries
Long term loan287,439,900.00151,611,367.8689.59%Mainly due to the increase of subsidiaries’ long-term borrowing
Other comprehensive income91,912,418.43-2,191,069.454294.87%Mainly due to the increase in the exchange differences from translation of foreign currency statements
Income statement itemAmount of the current periodAmount of the previous periodChange rateNotes on cause of changes
Gains on assets disposal-149,966.61304,146,257.99-100.05%Mainly due to the income from asset disposal of Sinclair in the previous period
Investment income-60,001,493.40-20,950,134.64-186.40%Mainly due to the increase of discount interest and the decrease of net profit of joint ventures in the current period
Cash flow statement itemAmount of the current periodAmount of the previous periodChange rateNotes on cause of changes
Net cash flows from investing activities-1,406,864,147.47-920,040,870.59-52.91%Mainly due to the increase of equity investment in the current period

II. Shareholder information(I) Total number of shareholders of common shares and number of shareholders of preferred shares with

voting rights restored, as well as information about top 10 shareholders

Unit: share

Total number of shareholders of common shares at the end of the reporting period195,693Total number of shareholders of preferred shares whose voting rights have been restored at the end of the0
reporting period (if any)
Information about top 10 shareholders
NameNatureShareholding ratioNumber of shares heldNumber of shares held with sale restrictionsPledged, marked or frozen
StatusNumber
China Grand Enterprises, Inc.Domestic non-state-owned legal person41.77%730,938,1570Pledged238,450,000
Hangzhou Huadong Medicine Group Co., Ltd.State-owned legal person16.46%288,000,0000
Hong Kong Securities Clearing Company Ltd.Overseas legal person1.75%30,641,9150
China Securities Finance Co., Ltd.Domestic non-state-owned legal person1.27%22,186,8180
National Social Security Fund Portfolio 503Others0.49%8,500,0860
#Liu LiDomestic natural persons0.34%6,000,0000
Basic Endowment Insurance Fund Portfolio 15041Others0.27%4,682,9500
#Chen ShaomingDomestic natural persons0.21%3,744,3880
Norges Bank-own fundsOverseas legal person0.16%2,776,2290
China Merchants Bank Co., Ltd.-Xingquanheyuan 2-year Holding Mixed Securities Investment FundOthers0.15%2,609,6390
Shares held by the top 10 shareholders of Non- restricted shares
NameNumber of shares held without sale restrictionsType of shares
TypeNumber
China Grand Enterprises, Inc.730,938,157RMB common shares730,938,157
Hangzhou Huadong Medicine Group Co., Ltd.288,000,000RMB common shares288,000,000
Hong Kong Securities Clearing Company Ltd.30,641,915RMB common shares30,641,915
China Securities Finance Co., Ltd.22,186,818RMB common shares22,186,818
National Social Security Fund Portfolio 5038,500,086RMB common shares8,500,086
#Liu Li6,000,000RMB common shares6,000,000
Basic Endowment Insurance Fund Portfolio 150414,682,950RMB common shares4,682,950
#Chen Shaoming3,744,388RMB common shares3,744,388
Norges Bank-own funds2,776,229RMB common shares2,776,229
China Merchants Bank Co., Ltd.-Xingquanheyuan 2-year Holding Mixed Securities Investment Fund2,609,639RMB common shares2,609,639
Notes on relations and concerted actions among the shareholders mentioned aboveThe Company does not know whether the shareholders mentioned above are related parties with each other or whether they are acting-in-concert parties with each other.
Notes on financing and securities loan conducted by top 10 shareholders (if any)At the end of the current reporting period, Liu Li, the sixth shareholder of the Company, held 6,000,000 shares of the Company through financing and securities loan, Chen Shaoming, the eighth shareholder of the Company, held 3,651,388 shares of the Company through financing and securities loan.

(II)Total number of shareholders of preferred shares and information about top 10 shareholders ofpreferred shares

□ Applicable √ N/A

III. Other important matters

√ Applicable □ N/A

(I) Overview of operations

1. The Company’s operations during the reporting period

In the first three quarters of 2021, the Company deepened the transformation and innovationwork. The performance of business indicators in the reporting period decreased year-on-year, buthas been significantly improved compared with the first half of the year, and the overall operationmaintained a stable and positive trend. The core subsidiary Zhongmei Huadong actively overcamethe business and market pressure brought about by the reform of the domestic pharmaceuticalindustry, accelerated the process of innovation and internationalization, and strengthened thedevelopment of out-of-hospital and grass-roots markets. In the first three quarters of 2021, theoperating income reached RMB7.804 billion, down 11.4% year on year, and the net profit wasRMB1.72 billion, down 11.1% year on year. While the sales volume of main products wasincreasing, the income from immunity and cardiovascular products continued to increase rapidly.The export of customized high-end bulk drugs (Contract Development and ManufacturingOrganization, CDMO) and e-commerce business continued to develop, reflecting the resilience andgrowth potential of the Company’s pharmaceutical manufacturing business as a whole. In the thirdquarter, Zhongmei Huadong was affected by product price reduction continuously, with theoperating income decreasing by 12.7% year on year but increasing by 2.0% quarter on quarter, andthe net profit decreasing by 5.2% year on year (compared with 14.6% year-on-year decline of thefirst quarter of 2021 and 11.7% year-on-year decline of the second quarter of 2021, indicating the

trend of narrowing decline and stabilization) but increasing by 14.8% quarter on quarter, which haslaid a solid foundation for returning to growth in 2022. In the fourth quarter, the Company willmake every effort to manage the operation, strive to achieve growth in the quarter, and endeavor toachieve the operating objectives of the whole year.Ellansé

?, the core aesthetic medicine product of the Company, has been officially placed onthe Chinese mainland market at the end of August. It has been accurately positioned for high-endregeneration market with its unique advantages of “immediate filling, lasting effect and beingmetabolizable”. Currently, the number of contracted cooperative hospitals for the product exceeds120, the number of trained and certified doctors exceeds 200, and its sales and promotion was ready.Ellansé

?

has received extensive attention and popularity from the market since its launch, with astack of orders from aesthetic medicine institutions and good feedback from customers. As of therelease date of this report, the Company has received advances of more than RMB100 million forthe product, and is expected to beat the annual sales target, and drive the Company’s domesticaesthetic medicine business to achieve new growth in 2022 based on the head start this year. Facingthe strong demand in the domestic market, the Company requires Sinclair’s Dutch factory to givepriority to the supply in the domestic market, thus shortening the waiting time of customers. At thesame time, the Company will strictly select cooperative institutions and constantly increase thetraining and certification of doctors to provide responsible and high-quality services to customers.Moreover, to meet the demand growth of Ellansé

?in the global market, in addition to the factory inUtrecht in the Netherlands, Sinclair built a new factory in Almere, Netherlands, to expand itscapacity. At present, the new factory is completed and put into use after passing the certification andapproval, so as to fully ensure the subsequent supply of Ellansé

?around the globe.During the reporting period, the Company’s overseas aesthetic medicine business continued toshow rapid growth with the relaxation of pandemic containment measures in various countries. Thesales of Ellansé

?, the core product of Sinclair UK, MaiLi

?series product, a newly-launchedhigh-end hyaluronic acid filler in Europe, Lanluma

?

, a collagen stimulant, and other productscontinued to outperform the expectation. In the first three quarters of 2021, Sinclair’s operatingincome (including acquired Spanish company High Tech) was GBP53.06 million (approximatelyRMB473 million) with a year-on-year increase of 127.4%. Specifically, Sinclair’s own incomeincreased by 79.24%, and its annual income is expected to reach the highest level in history. Drivenby good sales in the end market, High Tech received sufficient orders during the year, which hasprovided a strong guarantee for the rapid growth of annual income. In the first three quarters of2021, affected by factors such as non-recurring expenses for the acquisition of High Tech’s equities,Sinclair’s net profit in the overall consolidated statement still showed a loss, but its earnings before

interest, taxes, depreciation and amortization (i.e. EBITDA) was GBP5.06 million (consolidatedspecifications), the highest EBITDA since the Company completed the buyout of Sinclair in 2018,and also important evidence of the Company’s ability to run the aesthetic medicine business aroundthe globe.

Huadong Pharmaceutical Distribution Company has actively optimized the in-hospital marketand expanded the out-of-hospital market, and the overall business maintained a stable growth. In thefirst three quarters of 2021, the Company’s pharmaceutical commerce segment achieved anoperating income of RMB17.268 billion with a year-on-year increase of 7.03%. The establishmentof product promotion teams has been accelerated, and the number of innovative drugs introduced tosell by proxy during the year has exceeded that in 2020. The third-party logistics business ofpharmaceutical commerce continued with rapid growth, with the phased task of the distribution ofCOVID-19 vaccines in Zhejiang Province being fully completed. The construction of Jinhualogistics center entered the final stage. During the reporting period, the Company was also selectedas a key e-commerce platform enterprise in 2021-2022 in Zhejiang Province.The main reason for the difference between year-on-year decrease in the Company’s net profitand the net profit after deducting non-recurring profits and losses in the reporting period is that theCompany’s non-recurring profits and losses in the first quarter of 2020 were RMB290 million,including a net income of GBP30.65 million from the transfer of regional product distribution rightsby Sinclair to Galderma, which greatly increased the Company’s overall income in the first quarterof 2020. No such matters occurred during the reporting period, and other non-recurring gains andlosses totaled RMB133 million in the first three quarters of 2021, resulting in a decrease in the netprofit attributable to shareholders of the listed company year on year.

2. Building an R&D ecosystem of the Company and accelerating the process ofinnovation and internationalization

During the reporting period, Zhongmei Huadong and Huadong Medicine Investment Holding(Hong Kong) Co., Ltd. (hereinafter referred to as the “Investment Holding”), wholly-ownedsubsidiaries of the Company, signed an equity investment agreement and exclusive product licenseagreement with Ashvattha Therapeutic, Inc. (hereinafter referred to as “Ashvattha”). InvestmentHolding will subscribe for Series B preferred shares issued by Ashvattha in stages. Meanwhile,Zhongmei Huadong will obtain the exclusive license of Ashvattha’s 8 products under research in 20Asian countries and regions such as China, Singapore and Malaysia, including the use ofAshvattha’s relevant intellectual property rights for R&D, production and commercialization.

Ashvattha is an innovative biopharmaceutical enterprise focusing on the development ofhydroxyl dendrimer (HD) therapeutics (HDTs). Based on interdisciplinary transformation research

of dendrimers that can cross the tissue barrier, its scientific research team connects activepharmaceutical ingredients (API) or imaging agent with HD to form new patented drugs, which canachieve precise treatment by targeting disease cells and have clinical significance and applicationprospect. Ashvattha applies the technology of nanomedicine and nano materials. Its unique HDplatform is the only hydroxyl dendrimer platform capable of producing highly selective drugs in theworld. Ashvattha has a reasonable patent portfolio and has the potential to develop a variety oftherapeutic drugs.

Ashvattha was founded by three scientists, namely, Dr. Kannan Rangaramanujam, the ArnallPatz distinguished professor of ophthalmology and co-director of center for nanomedicine at theWilmer Eye Institute at Johns Hopkins School of Medicine, Dr. Sujatha Kannan, the Richard J.Traystman Professor and Vice chair of research in Anesthesiology and Critical Care Medicine(ACCM) at Johns Hopkins School of Medicine, and Dr. Jeffrey Cleland, who graduated fromMassachusetts Institute of Technology in chemical engineering, worked for Genentech andcommitted to new drug research and development for more than ten years. The three founders havemade achievements in the field of medicine, published a large number of academic articles andowned dozens of invention patents. In addition, Ashvattha also has a team of professionalconsultants with rich research experience and professional experience.The Company introduced eight products under research from Ashvattha, covering the fields oftumor, metabolic comorbidity, inflammation, etc.. One of the products has entered phase II clinicaltrial in the United States, and two products will be submitted for IND review in the United States inthe first quarter of 2022. This cooperation will further enrich the Company’s innovative productpipeline in the fields of tumor, immunity and endocrinology, and help to improve the Company’sinternationalization and scientific research innovation level. In the future, the products will alsoprovide doctors and patients with more precise and scientific diagnosis and treatment andmedication options after launching.The Company has invested, held shares in and incubated a number of domestic biotechnologycompanies with leading technology. For example, it invested in Peg-Bio Biopharm featuring apeptide technology platform, Qyuns Therapeutics, an antibody company focusing on immunediseases, and Nuoling Biomedical Technology featuring ADC linker and coupling technology; itincubated Huida Biotech which has a full line of toxin ingredients used to develop ADC drugs; andit holds stakes in Doer Biologics which focuses on the development of a Polyclonal antibodyplatform. Through those efforts, the Company has gradually formed its own medical R&Decosystem. The cooperation with Ashvattha and the introduction of its HD platform technology willbecome an important part of the Company’s efforts to build an R&D ecosystem and accelerate its

process of innovation and internationalization.

3. Continuing to enrich product lines and enhancing the competitiveness of diabetesmedicineDuring the reporting period, the application for marketing authorization regarding theindications for diabetes of the Company’s GLP-1 receptor agonist Liraglutide injection wasaccepted in September 2021. In addition to the original research company, there is no domesticmanufacturer applying for its marketing authorization. Therefore, the Company is expected tobecome the first enterprise in China to obtain approval for the marketing authorization ofLiraglutide’s biosimilar. Furthermore, the Company has carried out phase III clinical research on theindication for weight loss of Liraglutide injection. At present, the enrollment has been completedand a follow-up visit is underway. It is planned to carry out the application for marketingauthorization by the end of 2021.

In September 2021, the Company granted the exclusive development, production andcommercialization rights of the world’s first small-molecule oral GLP-1 receptor agonist TTP273 inKorea to Daewon Pharmaceutical Co., Ltd. of South Korea, which is the Company’s firstlicense-out of innovative products (see the relevant announcement issued by the Company onSeptember 30, 2021).

In October, the Company entered into strategic cooperation with Takeda PharmaceuticalsCompany Ltd. (hereinafter referred to as “Takeda”) on the commercialization rights of globallyinnovative DPP-4 inhibitor Nesina

?(Alogliptin Benzoate Tablets) in China, which has been

launched in China, further enriching the Company’s diabetes product portfolio, forming synergywith the Company’s existing key products in the field of diabetes, and continuously consolidatingand enhancing the competitiveness and leading position of the Company in the field of diabetesmedicine in China. The alliance with Takeda also shows the industry’s affirmation of thecommercialization ability of the Company in the local market of diabetes medicine.

The company has been engaged in the field of diabetes medicine for nearly 20 years, hasestablished a product matrix of core therapeutic targets and mainstream clinical drugs, and alreadyhas more than 20 commercialized products and products under research. The diabetes medicinemarket will continue to be a core area for the Company to expand its layout in the future. TheCompany will actively accelerate the process of innovation and industrialization throughindependent research and development, cooperation, equity investment and other diversified modes,continuously provide cutting-edge and advanced drugs in the world, continuously broaden the roadof internationalization and make progress towards the world’s leading diabetes medicinemanufacturing enterprise.

4. Building a non-invasive + minimally invasive high-end product pipeline to bring a newgrowth momentum to the global aesthetic medicine business

During the reporting period, Sinclair cooperated with KiOmed in Belgium to obtain theexclusive license of four globally innovative KiOmedine

?

chitosan products under research and allsubsequent chitosan related aesthetic medicine products in the field of aesthetic medicine for skin inother regions of the world except the United States, including the use of KiOmed related intellectualproperty rights for R&D, production and commercialization. The cooperation is another importantstrategic measure for global layout of the Company in the field of light aesthetic medicine, will

further enrich the Company’s innovative filler product pipeline of aesthetic medicine, and realizethe full coverage of products in the fields of hyaluronic acid, collagen stimulant, skin booster and soon. KiOmedine

?is a high-purity natural (non-animal-sourced) medical chitosan derivativedeveloped by KiOmed using its unique patented technology. Compared with hyaluronic acid,KiOmedine

?is characterized by deep moisturizing, increasing collagen level and anti-aging. Inaddition, KiOmedine

?series fillers are expected to further prolong the action time of hyaluronicacid and achieve long-acting filling effect. At present, there is no similar product in the market allover the world. The future launch of the product is expected to change the product landscape of thehyaluronic acid market and will become another potential blockbuster product in the field besideshigh-end hyaluronic acid MaiLi

?

.The Company introduced a cold-touch cosmetic instrument from R2 Company,

Glacial Spa

TM

(F0, life cosmetology version of a frozen freckle-removing medical device), has obtained marketingapproval in Korea and Taiwan of China, and the Non-medical Devices Management Certificationfrom NMPA. It is expected to be officially marketed in China in the fourth quarter of 2021.Cooperation intentions have been reached with some beauty institutions.In addition, the Company has made launching plans in China for the main products on saleoverseas and innovative products under research of the wholly-owned subsidiary High Tech inSpain engaged in energy source aesthetic medicine devices, and the relevant registrationpreparations have been carried out orderly. In particular, the registration of cryolipolysis productCooltech Define and laser hair removal device Primelase in China will be officially launched beforethe end of 2021. Safyre, an RF product marketed overseas and suitable for facial rejuvenation andbody shaping, is expected to be rolled out in China in the second quarter of 2022.

The Company will continue to accelerate the progress of clinical registration and promotion ofcore aesthetic medicine products at home and abroad, and continuously improve the competitiveadvantage in the industry by penetrating the global high-end aesthetic medicine market. After threeyears of rapid development, the Company’s aesthetic medicine business has achieved phasedstrategic objectives, and developed more than 20 products in the field of non-invasive + minimallyinvasive aesthetic medicine, with the number and coverage among the front rank of the industry. Ofthose products, several are expected to be released and sold at home and abroad before 2025,bringing new growth momentum to the Company’s global aesthetic medicine business.

Note 1: Due to the liquidation of Huadong Ningbo after its operations expire, there is still uncertainty about the subsequent ownership of the interests in the commercialization ofbotulinum toxin products in China with Jetema of South Korea.

肉毒素埋线
Ellansé?伊妍仕?注射用聚己内酯微球Lanluma?(聚左旋乳酸类胶原蛋白刺激剂)MaiLi?系列新型高端含利多卡因透明质酸Perfectha?系列双相透明质酸与Kylane公司合作两款重点研发产品皮肤动能素(天然<非动物源>羧烷基壳聚糖注射剂)3款KiOmedine?填充剂(天然<非动物源>羧烷基壳聚糖和透明质酸注射剂)Botulinum Toxin 1(A型肉毒素)美容埋线Silhouette?Instalift?
除皱适用于中面部提拉手术短暂固定并提拉脸颊下真皮位置
中国注册上市推进中美国 FDA 认证全球 60 多个国家获地区获注册认证或上市准入预计 2024 年在中国上市

填充皮肤美白提亮

脱毛脱毛脱毛
海外已上市海外研发阶段预计 2023 年获得欧盟 CE认证海外研发阶段预计 2024 年获得欧盟 CE认证海外研发阶段预计 2022年获得欧盟 CE认证预计2022年中国上市全球 11 个国家或地区获 注册认证或上市准入海外研发阶段预计 2023 年获得欧盟 CE认证全球 7 个国家或地区获注册认证或上市准入
皮肤管理身体塑形脱毛
酷雪?Glacial Spa?(F0)F1(Glacial Rx?)F2(Glacial Ai)CooltechCooltech DefineCrystileDefine2.0Define3.0TitaniaSafyrePrimelasePrimelase ProElysion

(II) Research and development and registrationDuring the reporting period, the Company continued to accelerate the R&D work, with a totalR&D investment of RMB904 million in the pharmaceutical industry, a year-on-year increase of

8.9%. The clinical study and registration of products under research in the Company’s core areas isadvancing in an orderly manner.As of the release of the report, the main R&D and registration progress of the Company’smedicine business is as follows:

1. Diabetes

The application for marketing authorization regarding the indication for diabetes of GLP-1receptor agonist Liraglutide injection was accepted in September 2021. The non-clinical study ofInsulin Aspart injection was completed, and it is expected that the application for IND review willbe submitted in the first quarter of 2022. HDM1003 (SCO-094) is a dual agonist that targets bothGLP-1R and GIPR for the treatment of diseases such as type 2 diabetes, obesity and non-alcoholicsteatohepatitis (NASH), jointly developed by the Company and SCOHIA PHARMA, Inc. in Japan.Its Phase I clinical trial is being carried out in the United Kingdom, and the Pre-IND application inChina has been submitted. DR10624 is a multiple agonist under research by the holding subsidiaryZhejiang Doer Biologics Corporation that targets GLP-1R/GCGR/FGF21, which can be used forthe treatment of diseases such as type 2 diabetes, obesity and NASH. The preparations of its phase Iclinical trial overseas and pre-IND application in China in 2022 are underway.

2. Tumor

HDM2002 (IMGN853), developed jointly by the Company and ImmunoGen of the UnitedStates, is the world’s first ADC drug for FR α-positive ovarian cancer. Its phase III multi-regionalclinical trial has been initiated in China, and it is expected that clinical enrollment will be completedin 2022. The clinical enrollment of another key single-arm clinical trial of the drug has beencompleted in the United States and Europe in the second quarter, and preliminary test results areexpected to be obtained by the end of 2021. Mefatinib for the treatment of advanced non-small celllung cancer is under phase III clinical trial, and the enrollment of the subjects for the phase IIIclinical trial has been completed. It is expected to carry out application for marketing authorizationafter the completion of phase III clinical trial in 2022. DR30303 is a product under research of theholding subsidiary Zhejiang Doer Biologics Corporation for the treatment of gastric cancer andpancreatic cancer, and feedback has been received from CDE concerning its application forpre-IND. Its phase I clinical trial will be launched in China in 2022 after IND approval.

3. Autoimmunity

The Company introduced HDM3002 (PRV-3279), a bispecific antibody under research of

Provention Bio (USA) for the treatment of systemic lupus erythematosus (SLE) and for preventingor reducing the immunogenicity of gene therapy. At present, pre-IND materials have been submittedin China and feedback has been received. The phase II multi-regional clinical trial of this productwill be initiated in China. HDM3001 (QX001S) is a biosimilar of the original drug ustekinumab(Stelara?) jointly developed by the Company and its partially-owned company Qyuns Therapeuticsand used to treat moderate-to-severe psoriasis of adults. Its phase III clinical trial is underway.

4. Rare diseases

Sirolimus Oral Solution produced by the Company has been used clinically to treat a rarepediatric disease tuberous sclerosis complex (TSC) for many years. In view of the urgent clinicalneeds of children with TSC for approved effective treatment, the Company has submitted a pre-INDapplication to CDE and plans to carry out a real-world study to support the expansion of theindications.

5. Medicine/medical device

HD-NP-102 (MB102, dynamic TGFR monitoring system): A product jointly developed by theCompany and Medibeacon, Inc. of the United States for the evaluation of the renal function ofhealthy people and patients through real-time percutaneous monitoring of glomerular filtration rate.With its accurate diagnosis and risk assessment of early renal injury, the product is ofground-breaking clinical significance. The Company has submitted an application for innovativemedical devices to the Center for Medical Device Evaluation of National Medical ProductsAdministration, and the phase III multi-regional clinical trial will be launched by the end of 2021.

(III) Other important matters

In August 2021, the natural person shareholders of the Company’s holding subsidiary HuadongNingbo Medicine Co., Ltd. (hereinafter referred to as “Huadong Ningbo”) filed a lawsuit to thePeople’s Court of Beilun District of Ningbo for an order to dissolve Huadong Ningbo in advance onthe grounds that there were serious difficulties in the operation and management of HuadongNingbo and that the continuing operation of Huadong Ningbo would cause material losses toshareholders. The Company claimed that Huadong Ningbo should enter the legal liquidation afterits operation expires on December 31, 2021, but did not agree to dissolve Huadong Ningbo inadvance. The case was heard in People’s Court of Beilun District of Ningbo on September 22, 2021,and has not been sentenced yet. Afterward, the Company held meetings with natural personshareholders and management representatives of Huadong Ningbo on relevant matters. The twoparties have reached a consensus that Huadong Ningbo has entered the liquidation preparationperiod, will mainly carry out capital withdrawal before the end of 2021, and will not conduct newbusiness. The parties agree to speed up the preparations for the liquidation of Huadong Ningbo. To

be responsible to all shareholders and safeguard the interests of all shareholders, the Company willproperly carry out the subsequent liquidation of Huadong Ningbo according to law.IV. Quarterly financial statements

(I) Financial Statements

1. Consolidated balance sheet

Prepared by Huadong Medicine Co., Ltd.

Unit: RMB yuan

ItemSeptember 31, 2021December 31, 2020
Current assets:
Monetary funds3,366,668,781.243,198,080,997.82
Settlement reserve
Lending to other banks and other financial institutions
Financial assets for trade
Derivative financial assets
Notes receivable
Accounts receivable8,147,812,875.636,137,675,568.82
Accounts receivable financing572,080,968.64828,659,217.25
Advance payments291,583,511.06250,916,482.07
Premiums receivable
Reinsurance accounts receivable
Reinsurance contract reserve receivable
Other receivables299,688,469.5487,269,489.82
Including: Interests receivable15,972,701.53
Dividends receivable832,286.374,195,666.37
Financial assets purchased for resale
Inventories4,129,417,606.734,067,635,254.80
Contract assets
Assets held for sale
Non-current assets due within one
year
Other current assets38,039,156.5285,654,691.58
Total current assets16,845,291,369.3614,655,891,702.16
Non-current assets:
Loans and prepayments issuance
Debt investments
Other debt investments
Long-term receivables
Long-term equity investments950,889,474.55850,072,053.02
Other equity instrument investments129,841,291.42225,453,120.05
Other non-current financial assets
Real estate properties for investment17,082,267.9517,792,735.95
Fixed assets3,106,575,021.332,420,366,582.92
Constructions in progress1,864,058,365.392,240,201,926.65
Biological assets for production
Oil & gas assets
Right-of-use assets161,568,723.35
Intangible assets1,707,792,705.741,463,242,463.99
Development expenditures
Goodwill2,100,106,651.091,469,617,262.10
Long-term unamortized expenses10,511,051.568,811,339.43
Deferred income tax assets151,508,607.37137,829,774.40
Other non-current assets642,486,393.70712,069,194.08
Total non-current assets10,842,420,553.459,545,456,452.59
Total assets27,687,711,922.8124,201,348,154.75
Current liabilities:
Short-term borrowing1,280,558,172.041,416,932,884.87
Borrowing from the Central bank
Borrowing from other banks and other financial institutions
Financial liabilities for trade
Derivative financial liabilities
Notes payable1,381,336,643.84554,336,058.71
Accounts payable4,292,982,588.653,947,044,331.68
Advance receipts1,906,357.52951,926.56
Contract liabilities186,487,690.0294,384,629.77
Financial assets sold for repurchase
Absorbing deposits and due from banks
Receipts for buying and selling securities as proxy
Receipts for underwriting securities as proxy
Employee benefits payable160,461,686.62152,106,819.91
Taxes and fees payable565,343,178.21571,792,475.80
Other payables2,084,232,842.011,817,529,820.99
Including: Interests payable
Dividends payable224,219.60224,219.60
Handling fees and commissions payable
Reinsurance accounts payable
Liabilities held for sale
Non-current liabilities due within one year23,288,386.1167,813,886.68
Other current liabilities30,059,800.6410,786,034.37
Total current liabilities10,006,657,345.668,633,678,869.34
Non-current liabilities:
Insurance contract reserve
Long-term borrowing287,439,900.00151,611,367.86
Bonds payable
Including: Preferred shares
Perpetual bonds
Lease liabilities148,719,237.87
Long-term payables164,454,591.4826,812,354.90
Long-term employee benefits payable
Provision37,410,969.9539,467,829.23
Deferred gains83,907,277.3381,628,032.54
Deferred income tax liabilities83,108,397.2988,738,187.41
Other non-current liabilities
Total non-current liabilities805,040,373.92388,257,771.94
Total liabilities10,811,697,719.589,021,936,641.28
Ownership interest:
Share capital1,749,809,548.001,749,809,548.00
Other equity instruments
Including: Preferred shares
Perpetual bonds
Capital reserve2,158,080,661.072,158,080,661.07
Less: Treasury shares
Other comprehensive income91,912,418.43-2,191,069.45
Special reserve
Surplus reserve863,793,516.20861,680,578.42
General risk reserve
Undistributed profit11,386,989,359.189,852,441,590.56
Total ownership interest attributable to the parent company16,250,585,502.8814,619,821,308.60
Minority interest625,428,700.35559,590,204.87
Total ownership interest16,876,014,203.2315,179,411,513.47
Total liabilities & ownership interest27,687,711,922.8124,201,348,154.75

Legal representative: Lv LiangOfficer in charge of accounting: Lv LiangHead of accounting department : Qiu Renbo

2. Consolidated income statement from the beginning of the year to the end of the reporting period

Unit: RMB yuan

ItemAmount incurred during the current periodAmount incurred during the previous period
I. Total operating income25,927,477,363.2725,500,876,607.95
Including: Operating income25,927,477,363.2725,500,876,607.95
Interests received
Premiums earned
Handling fees and commissions received
II. Total operating cost23,721,020,429.0422,945,770,445.69
Including: Operating cost17,820,264,592.1216,739,900,305.18
Interests paid
Handling fees and commissions paid
Surrender value
Net payment of insurance claims
Net appropriation of policy reserve
Policy dividends paid
Reinsurance expenses
Taxes and surcharges132,071,642.16148,487,687.03
Selling expenses4,165,255,628.174,575,928,264.87
Administrative expenses859,932,896.49775,033,097.55
R&D expenses727,596,640.52689,897,925.27
Financial expenses15,899,029.5816,523,165.79
Including: Interests paid59,960,711.5559,381,737.63
Interests received64,850,873.7452,891,384.64
Add: Other gains157,965,604.53123,759,645.82
Investment gains (Losses are indicated by “-”)-60,001,493.40-20,950,134.64
Including: Investment gains from associates and joint ventures-18,970,341.98-9,025,650.76
Gains from the derecognition of financial assets measured at amortized cost
Gains on exchange (Losses are indicated by “-”)
Gains on net exposure hedging (Losses are indicated by “-”)
Gains on changes in fair value (Losses are indicated by “-”)
Credit impairment loss (Losses are indicated by “-”)-38,263,673.24-29,841,283.63
Assets impairment loss (Losses are indicated by “-”)3,054,806.20
Gains on assets disposal (Losses are indicated by “-”)-149,966.61304,146,257.99
III. Operating profit (Losses are indicated by “-”)2,269,062,211.712,932,220,647.80
Add: Non-operating income17,439,095.8616,504,085.99
Less: Non-operating expenditure19,888,568.8926,367,259.87
IV. Total profit (Total losses are indicated by “-”)2,266,612,738.682,922,357,473.92
Less: Income tax expenses324,435,752.43462,041,510.71
V. Net profit (Net losses are indicated by “-”)1,942,176,986.252,460,315,963.21
(I) Categorized by the continuity of operations
1. Net profit from continued operations (Net deficit is indicated by “-”)1,942,176,986.252,460,315,963.21
2. Net profit from discontinued operations (Net deficit is indicated by “-”)
(II) Categorized by attribution of the ownership
1. Net profit attributable to owners of the parent company1,895,384,579.342,391,466,604.78
2. Gains/losses of minority shareholders46,792,406.9168,849,358.43
VI. Net amount after tax of other comprehensive income115,596,732.4821,024,507.92
Net amount after tax of other comprehensive income attributable to owners of the parent company115,596,732.4821,024,507.92
(I) Other comprehensive income that cannot be reclassified into gains/losses18,270,393.865,817,290.26
1. Changes in remeasurement on the defined benefit plan
2. Other comprehensive income that cannot be reclassified into gains/losses under equity method
3. Changes in fair value of18,270,393.865,817,290.26
other equity instrument investments
4. Changes in fair value of credit risk of the enterprise
5. Others
(II) Other comprehensive income to be reclassified into gains/losses97,326,338.6215,207,217.66
1. Other comprehensive income that can be reclassified into gains/losses under equity method
2. Changes in fair value of other debt investments
3. Amount of financial assets reclassified into other comprehensive income
4. Credit impairment reserve of other debt investments
5. Cash flow hedging reserve
6. Exchange differences arise from translation of foreign currency financial statements97,326,338.6215,207,217.66
7. Others
Net amount after tax of other comprehensive income attributable to minority shareholders
VII. Total comprehensive income2,057,773,718.732,481,340,471.13
Total comprehensive income attributable to owners of the parent company2,010,981,311.822,412,491,112.70
Total comprehensive income attributable to minority shareholders46,792,406.9168,849,358.43
VIII. Earnings per share (EPS):
(I) Basic EPS1.08321.3667
(II) Diluted EPS1.08321.3667

As for enterprise merger under the same control in the current period, the net profit generated by the merged party before the mergeris 0 yuan, and that generated during the previous period is 0 yuan.

Legal representative: Lv LiangOfficer in charge of accounting: Lv LiangHead of accounting department : Qiu Renbo

3. Consolidated cash flow statement from the beginning of the year to the end of the reporting period

Unit: RMB yuan

ItemAmount incurred during the current periodAmount incurred during the previous period
I. Cash flows from operating activities:
Cash from the sale of goods and provision of services27,674,577,148.0426,358,487,943.05
Net increase in customer deposits and due from banks
Net increase in borrowing from the central bank
Net increase in borrowing from other financial institutions
Cash from the premium of the original insurance policy
Net cash from reinsurance
Net increase in deposits and investment of the insured
Cash from interests, handling fees and commissions
Net increase in borrowing from other banks and other financial institutions
Net increase in funds for repurchase
Net cash received for buying and selling securities as proxy
Tax refund received11,649,988.9717,066,804.84
Other cash receipts in relation to operating activities529,610,507.12862,918,296.18
Total cash inflows from operating activities28,215,837,644.1327,238,473,044.07
Cash payments for goods and services18,596,693,102.8817,276,216,270.79
Net increase in customer loans and prepayments
Net increase in deposits of central bank and due from banks
Cash for payment of original insurance claims
Net increase in lending to other banks and other financial institutions
Cash for payment of interests, handling fees and commissions
Cash for payment of policy dividends
Cash payments to and for employees1,822,563,793.721,623,091,615.04
Payment of taxes and fees1,531,826,498.861,795,768,635.77
Other cash payments in relation to operating activities4,158,837,421.954,641,582,165.81
Total cash outflows for operating activities26,109,920,817.4125,336,658,687.41
Net cash flows from operating activities2,105,916,826.721,901,814,356.66
II. Cash flows from investing activities
Cash from recovery of investments20,432,161.82
Cash from investment gains4,281,616.50900,000.00
Net cash from disposal of fixed assets, intangible assets and other long-term assets2,009,441.20349,442,817.74
Net cash from disposal of subsidiaries and other business units
Other cash receipts in relation to investing activities29,602,856.85
Total cash inflows from investing activities56,326,076.37350,342,817.74
Cash payments for purchase and construction of fixed assets, intangible assets and other long-term assets539,567,188.77864,848,688.33
Cash payments for investment120,706,000.0070,535,000.00
Net increase in pledge loans
Net cash paid for acquisition of subsidiaries and other business units776,789,194.67335,000,000.00
Other cash payments in relation to investing activities26,127,840.40
Total cash outflows for investing1,463,190,223.841,270,383,688.33
activities
Net cash flows from investing activities-1,406,864,147.47-920,040,870.59
III. Cash flows from financing activities:
Cash from absorbing investments
Including: Cash from absorption of minority shareholders’ investments by subsidiaries
Cash from borrowing1,854,078,657.432,044,165,545.94
Other cash receipts in relation to financing activities360,000,000.00340,000,000.00
Total cash inflows from financing activities2,214,078,657.432,384,165,545.94
Cash for repayment of debt1,874,703,029.582,161,566,863.78
Cash payments for dividends, profits or interests499,317,003.89612,515,321.94
Including: Payment of dividends and profits by subsidiaries to minority shareholders49,000,000.00
Other cash payments in relation to financing activities365,675,774.15357,318,045.74
Total cash outflows for financing activities2,739,695,807.623,131,400,231.46
Net cash flows from financing activities-525,617,150.19-747,234,685.52
IV. Influence of exchange rate fluctuations on cash and cash equivalents-1,383,998.814,496,816.65
V. Net increase in cash and cash equivalents172,051,530.25239,035,617.20
Add: Balance of cash and cash equivalents at the beginning of the period3,157,407,073.262,231,771,546.50
VI. Balance of cash and cash equivalents at the end of the period3,329,458,603.512,470,807,163.70

(II) Notes on adjustments of financial statements

1、Adjustments to financial statement items at the beginning of the year of the first implementation of the newaccounting standards governing leases which have been implemented since 2021

√ Applicable ?N/A

Whether any balance sheet items at the beginning of the year requires adjustment

√Yes □ No

Consolidated balance sheet

Unit: RMB yuan

ItemDecember 31, 2020January 1, 2021Adjustment
Current assets:
Cahs and bank balances3,198,080,997.823,198,080,997.82
Settlement reserve
Lending to other banks and other financial institutions
Financial assets for trade
Derivative financial assets
Notes receivable
Accounts receivable6,137,675,568.826,137,675,568.82
Accounts receivable for financing828,659,217.25828,659,217.25
Prepayments250,916,482.07238,357,844.74-12,558,637.33
Premiums receivable
Reinsurance accounts receivable
Reinsurance contract reserve receivable
Other receivables87,269,489.8287,269,489.82
Including: Interests receivable
Dividends receivable4,195,666.374,195,666.37
Financial assets purchased for resale
Inventories4,067,635,254.804,067,635,254.80
Contract assets
Assets held for sale
Non-current assets due within one year
Other current assets85,654,691.5885,654,691.58
Total current assets14,655,891,702.1614,643,333,064.83-12,558,637.33
Non-current assets:
Loans and prepayments issuance
Debt investments
Other debt investments
Long-term receivables
Long-term equity investments850,072,053.02850,072,053.02
Other equity instrument investments225,453,120.05225,453,120.05
Other non-current financial assets
Real estate properties for investment17,792,735.9517,792,735.95
Fixed assets2,420,366,582.922,420,366,582.92
Constructions in progress2,240,201,926.652,240,201,926.65
Biological assets for production
Oil & gas assets
Right-of-use assets140,149,561.51140,149,561.51
Intangible assets1,463,242,463.991,463,242,463.99
Development expenditures1,469,617,262.10
Goodwill1,469,617,262.10
Long-term unamortized expenses8,811,339.438,811,339.43
Deferred tax assets137,829,774.40137,829,774.40
Other non-current assets712,069,194.08712,069,194.08
Total non-current assets9,545,456,452.599,685,606,014.10140,149,561.51
Total assets24,201,348,154.7524,328,939,078.93127,590,924.18
Current liabilities:
Short-term borrowing1,416,932,884.871,416,932,884.87
Borrowing from the central bank
Borrowing from other banks and other financial institutions
Financial liabilities for trade
Derivative financial liabilities
Notes payable554,336,058.71554,336,058.71
Accounts payable3,947,044,331.683,947,044,331.68
Receipts in Advance951,926.56951,926.56
Contract liabilities94,384,629.7794,384,629.77
Financial assets sold for repurchase
Absorbing deposits and due from banks
Receipts for buying and selling securities as proxy
Receipts for underwriting securities as proxy
Payroll payable152,106,819.91152,106,819.91
Taxes payable571,792,475.80571,792,475.80
Other payables1,817,529,820.991,817,529,820.99
Including: Interests payable
Dividends payable224,219.60224,219.60
Handling fees and commissions payable
Reinsurance accounts payable
Liabilities held for sale
Non-current liabilities due within one year67,813,886.6867,813,886.68
Other current liabilities10,786,034.3710,786,034.37
Total current liabilities8,633,678,869.348,633,678,869.34
Non-current liabilities:
Insurance policy reserve
Long-term borrowing151,611,367.86151,611,367.86
Bonds payable
Including: Preferred shares
Perpetual bonds
Lease liabilities127,590,924.18127,590,924.18
Long-term payables26,812,354.9026,812,354.90
Long-term employee benefits payable
Estimated liabilities39,467,829.2339,467,829.23
Deferred income81,628,032.5481,628,032.54
Deferred tax liabilities88,738,187.4188,738,187.41
Other non-current liabilities
Total non-current liabilities388,257,771.94515,848,696.12127,590,924.18
Total liabilities9,021,936,641.289,149,527,565.46127,590,924.18
Owners’ Equity:
Share capital1,749,809,548.001,749,809,548.00
Other equity instruments
Including: Preferred shares
Perpetual bonds
Capital reserves2,158,080,661.072,158,080,661.07
Less: Treasury shares
Other comprehensive income-2,191,069.45-2,191,069.45
Special reserve
Surplus reserves861,680,578.42861,680,578.42
General risk reserve
Retained earnings9,852,441,590.569,852,441,590.56
Total owners’ equity attributable to owner of the Company14,619,821,308.6014,619,821,308.60
Minority interest559,590,204.8714,619,821,308.60
Total owners’ equity15,179,411,513.4715,179,411,513.47
Total liabilities & owners’ equity24,201,348,154.7524,328,939,078.93127,590,924.18

Adjustment description

2、Retrospective adjustments to comparative data of the previous period due to the first implementation of the newaccounting standards leases since 2021

□ Applicable √ N/A

(III)Audit reportHas the third quarterly report been audited?

□ Yes √ No

The third quarterly report has not been audited.

The Board of Directors of Huadong Medicine Co., Ltd.

October 27, 2021


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