BeiGene, Ltd.
06160
2022630
20226302021
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2021630429.083.9%
82.1
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591.9143.0%1,005.7? 20226300.75
20216300.35114.3%
20222021
13566,084244,741 382,114511,123 648,198755,864
136,41068,948 768,122676,817 625,976414,395 376375 1,530,8841,160,535
(882,686)(404,671) 21,502(9,045) (117,650)(4,990)
(978,834)(418,706)926,889(4,860)
(1,005,723)(413,846)
(0.75)(0.35)151,334,252,6481,191,521,766
(9.80)(4.52) 102,634,81991,655,520
20222021
(1,005,723)(413,846) (88,085)5,864 –361 (12,315)(1,072)
(1,106,123)(408,693)
202220216301231
4,531,1374,375,678 4333328 41,172,5542,241,962 5172,259483,113 6262,210242,626 10207,383270,173
6,345,8767,613,880
43,9396,881 7633,100587,605 117,583117,431 843,32546,679 9103,429110,424 10130,955163,049
1,032,3311,032,0697,378,2078,645,949
11234,355262,400 10454,183558,055 3163,396187,414 915,56421,395 24,78821,925 3125,394120,801 12380,729427,565
1,398,4091,599,555
202220216301231
12185,207202,113 3167,570220,289 41,92143,041 914,73914,169 3219,385269,561 1048,43254,234
677,254803,4072,075,6632,402,962
0.0001 9,500,000,000 202263020211231 1,349,639,439 1,334,804,281134133 11,356,68611,191,007 17(82,450)17,950 (5,971,826)(4,966,103)
5,302,5446,242,9877,378,2078,645,949
20222021
(1,005,723)(413,846)
32,06121,159 16146,860110,624 423,5296,033 –53,500 3(45,583)(53,902) 7,550(12,311) 6,36011,212 307,430(13,338) (31,633)(28,294) 32,315(77,204) (30,362)(42,558) 19,5251,688 (76,737)138,877 (2,114)3,189
(616,522)(295,171)
(95,421)(80,920) (11,504)(1,357,051) 1,051,0281,997,515 (75,000)(8,500) –(7,500)
869,103543,544
20222021
12–10,819 1267,586112,589 12(115,405)(15,959) 18,97235,601
(28,847)143,050(71,212)5,257152,522396,6804,382,8871,390,0054,535,4091,786,685
4,531,1371,776,448 333310 3,9399,927 24,43614,527 12,89914,267 58,67628,885 –45,000
202112311,334,804,28113311,191,00717,950(4,966,103)6,242,987
––(152)––(152)2,165,904––––– 12,669,254118,971––18,972
––146,860––146,860
–––(100,400)–(100,400)
––––(1,005,723)(1,005,723)20226301,349,639,43913411,356,686(82,450)(5,971,826)5,302,544202012311,190,821,9411187,414,9326,942(3,552,749)3,869,243
(1,722,773)––––– 15,467,855235,599––35,601
––110,624––110,624–––5,153–5,153––––(413,846)(413,846)20216301,204,567,0231207,561,15512,095(3,966,595)3,606,775
1.
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2,5004080
16,000
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8,600202263045
BeiGene 101–100%BeiGene AUS Pty Ltd BeiGene Australia
56,947,230100%
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*10,450,000,000100%BeiGene (Canada) ULC100100%
BeiGene ESP, S.L.3,000100%BeiGene France Sarl7,500100%
*8,870,000,000100%
*263,000,000100%BeiGene Germany GmbH25,000100%BeiGene (Hong Kong) Co., Limited
7,700,000,000
100%
*4,000,000100%BeiGene International GmbH20,000100%BeiGene (Italy) S.R.L10,000100%BeiGene Brazil Ltda.2,450,190100%BeiGene Poland sp. z o.o.5,000100%BeiGene Sweden AB25,000100%BeiGene Turkey Medical Products Trade Limited Company
10,000100%BeiGene Ireland Limited BeiGene Ireland
–100%BeiGene Japan, Ltd.1,781,660100%BeiGene Korea Y.H.100,000,000100%BeiGene Netherlands B.V–100%
BeiGene NZ Unlimited BeiGene NZ, Limited
100,000100%BeiGene Pharmaceuticals GmbH20,000100%
*3,800,000100%BeiGene Pharmaceuticals Israel Limited–100%
*7,000,000100%
*1,000,000100%
*934,344,311100%
*–100%
*270,000,000100%BeiGene Singapore Pte. Ltd.1100%
*2,673,218,389100%BeiGene Switzerland GmbH BeiGene Switzerland
20,000100%168,000,000100%BeiGene UK, Ltd.BeiGene UK142100%BeiGene United Kingdom, Ltd.110100%BeiGene USA, Inc.BeiGene USA1100%BeiGene US Holdings, LLC–100%
BeiGene US Manufacturing Co., Inc.156,000,000100%BeiGene Hopewell Urban Renewal, LLC115,000,000100%Pi Health, Ltd.12,000,000100%Pi Health USA, LLC5,000,000100%B10 Health Technologies Private Limited–100%Newco 101–100%*
20226302022202163020222021630
20222021630
10-QS-X102021123110-K
20226
2021112021-10
20211215
20211231
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202263020211231
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20211231123
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2,241,962––
4:
23,80910,306–
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Leap Therapeutics, Inc.Leap
2020120219LeapLeap
1Leap2
202263020211231
3.
20222021630
20222021630
20222021
–484,64624,24026,47752,497–5,377–82,114511,123
20211
650,000,0001,300,000,000250,000,000
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650,000,000
1,231,000,000420,000,000484,646,000165,354,000
2021630
2021630
202263020,656,000202163026,477,00020226305,377,000
202112
TIGIT
?????
202220221300,000,000202320232023600,000,000700,000,000
745,000,0001,150,000,000
50%25%
(1)(2)
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300,000,000
71,980,000213,450,00014,570,000
2022630
52,497,00020226303,584,000
201910
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202012
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?XGEVA
?2019202011
20207?
202012
?
B20217
?20224
?
CD19B
1,250,000,000KRAS G12CLUMAKRAS?(sotorasib)LUMAKRAS?
100%
2022420
201910202012174.8515,895,00120.5%Anthony Hooper20201
132.742,109,902,000
601,857,0002,779,241,0002,162,407,000616,834,000
20222021630
20222021
46,78955,33045,58353,90392,372109,233
2022
698,687202263020211231
202220216301231125,394120,801219,385269,561344,779390,36220222021630
20222021
3,47867889863
(26,642)(15,917)
(22,266)(15,176)202263030,061,000202163018,854,000
202263020211231101,580,000106,790,000
4.
2022630202112314,272,0007,209,000
2022630
1,184,869–12,3151,172,5541,184,869–12,3151,172,554
20211231
2,245,662–3,7002,241,9622,245,662–3,7002,241,962
20226302022630
Leap Therapeutics, Inc. (Leap)
20201Leap5,000,000Leap BB20203LeapLeap20219Leap
7,250,000Leap2022630Leap8.3%
Leap13.1%202263022,661,0002021630
5,376,000202263020211231
202220216301231Leap8,45123,809Leap3,00310,306
20226302021123144,033,00043,722,0002022630
366,000
20226302021123127,100,00022,955,000
20226301,234,0002021630657,000
5.
202220216301231172,467483,528
(208)(415)
172,259483,1134590
2022202163012313171,294483,0583696555
172,259483,113
20222021630
20222021
415112
(210)(46)
––
20867
6.
202220216301231
82,84878,14037,9929,397
141,370155,089262,210242,6267.
202220216301231
65,48565,485
131,885118,20350,87850,288
179,495144,083
138,478119,58536,47327,404602,694525,048(142,561)(124,286)
172,967186,843633,100587,605
20211175,197,00042
202263030,041,0002021630
20,667,0008.
202263020211231
202263020211231
7,500(3,625)3,8757,500(3,250)4,250 42,016(2,566)39,45043,394(965)42,429 816(816)–816(816)–
50,332(7,007)43,32551,710(5,031)46,679BMS
2018920202
20242
202220211,6441173763752,020492
2022630123120221,6143751,98920233,2227503,97220243,2227503,97220253,2227503,97220263,2227503,972202724,94850025,448
39,4503,87543,325
9.
202263026,889,0002021630
4,860,0002022630
2021
2022630
202263011,765,00012
20226301,840,000
202263020211231
2022630201320222012202220182022
20152022
20112022
10.
20222021630123172,47487,23959,29178,53818,62758,57917,40912,010
2,6115,0528,4621,69528,50927,060
207,383270,173
202220216301231
10910914,41214,140
(1)21,47324,237
2917,1627,3456,609487,587100,792
130,955163,049(1)
202220216301231
124,565139,966
151,321213,92255,36671,56023,52545,66171,51259,63927,89427,307454,183558,055
202220216301231
40,83546,3527,4847,8141136848,43254,234
11.
2022202163012313229,217257,977361,7253,210613,1371,1101276103
234,355262,400
12.
202263020211231
202263020211231
201844580,0009202744(1)4,33029,0001,2558,0002020122(2)92029120(2)1,49310,0001,56910,0002020119378,00092029118(3)2,61317,500––2020924200,000(4)4.5%200,0001,339,585200,0001,274,5352020924500,000(5)4.5%14,930100,00015,693100,000202222550,000120232252.2%50,000334,896––
(6)107,363719,115209,0481,332,197
380,7292,550,096427,5652,724,732201844580,0009202744(1)81,368545,00089,444570,0002020122(2)92029120(2)50,016335,00053,353340,0002020119378,00092029118(3)53,823360,50059,316378,000
185,2071,240,500202,1131,288,000
1. 2022630
4.9%
2022630598,0004,000,000
2. 2020122
1,100,000,000202012311,100,000,000350,000,00020226304.4%
2022630771,0005,000,000
201733
3. 2022630
4.3%
4. 20209200,000,000
120,000,00080,000,000202110820211082022108
20171
5. 20209
73,640,000500,000,00014,728,000100,000,00058,912,000400,000,000
(i)2021119(ii)2021108(i)2022119
(ii)Hillhouse CapitalHillhouse CapitalHillhouseCapital
6. 2021123120201231
1,760,000,00020214192023524202263017,586,000117,000,000114,036,000730,082,0002022630
4.1%
202263010,984,0001,935,000
202163014,577,000251,000
13.
?????????
20222021630
20222021638,273291,794
(72,189)(47,053)566,084244,74120222021630
20222021?
233,07264,513?
192,522123,758?
41,57626,775?
29,00817,792?
19,798–?
21,396–?
8,405–?
8,9466,961?
4,5772,221
6,7842,721566,084244,74120222021630
2022202159,63911,87472,18947,053(60,316)(33,355)71,51225,572
14.
20222021136,41068,948
30,04120,784768,122676,81713,36610,1412,020375489,416316,935146,860110,63225,96617,523662,242445,090118,3552,460(32,520)(5,534)
73–
20222021630293,291,000220,110,000
15.
20222021
(1,005,723)(413,846) 1,334,252,6481,191,521,76620222021630
16.
201620161NASDAQ(IPO)
201620162016265,029,5952016201120112016
2011
2022630201120165,166,510201812201638,553,159
20206201657,200,000
203041320162022630201612,159,74533,193,77120226302016
63,489,64957,144,9062022630201674,479,333
20162016
201666,300,00020223315%20226222018
201862018201812,000,000
5635(c)(4)
5635(c)(4)20182018
201620188
2018202263020182022630201830,901408,408201620182022622
20182018620183,500,000201812
3,855,3157,355,3152019620216
202191
15%
10%20226304,527,386
2022228667,160210.5216.19178.9413.769,1832021831425,386308.3023.72262.0620.168,5752021226436,124236.3018.18200.8615.456,738
20222021630
2022202167,96552,08278,89558,542146,860110,624
17.
2021123127,898(3,700)(6,248)17,950
(88,085)(12,315)–(100,400) ––––
(88,085)(12,315)–(100,400)2022630(60,187)(16,015)(6,248)(82,450)
18.
2019103120191262020924
20219165,5292,151,87750,000,000
202112
192.60391.68115,055,2603,392,616,000
19.
10%50%
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2022630109,700,00065,020,00044,680,000
2022630308,141,000
1,250,000,0002022630698,687,000
20216
202263025,173,000
15,000,000202263012,750,000
20226301,536,000
CRO
21.
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20222021630(i)50,000202150,000(ii)75,000202175,000(iii)2,141,00020212,271,000(b)
202220213,4232,945376519,62617,63523,08620,645
22.
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20222021630202263057,480,000
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2022630
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2021630
(i)(iii)(676,817)34,210–(642,607)(414,395)18,197–(396,198)(418,706)52,407–(366,299)
4,860(4,125)(21,801)(21,066)(413,846)48,282(21,801)(387,365)(413,846)48,282(21,801)(387,365)
2022630
(i)(ii)(iii)103,4291,082–(9,662)110,169
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20211231
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5,253––
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(i)
2022630
9,564,000202163052,407,0002022630
1,082,00020216304,125,00020211231
174,049,00015,320,000158,729,00020211231
202211
(ii)
20162307,894,000
307,894,000
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2016-09
2022630
9,662,0002021630
20226301,723,000202163021,801,00020211231136,055,000136,055,000202211(iv)
201911
20226302022630(v)
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ADS
202112
20222021630
20222021%
566,084244,741321,343131.3% 82,114511,123(429,009)(83.9)%
648,198755,864(107,666)(14.2)%
136,41068,94867,46297.8% 768,122676,81791,30513.5% 625,976414,395211,58151.1% 37637510.3%
1,530,8841,160,535370,34931.9%
(882,686)(404,671)(478,015)118.1% 21,502(9,045)30,547(337.7)% (117,650)(4,990)(112,660)2,257.7%
(978,834)(418,706)(560,128)133.8%
26,889(4,860)31,749(653.3)%(1,005,723)(413,846)(591,877)143.0%
20212022630
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648,198755,864(107,666)(14.2)%
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?
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192,522123,75868,76455.6%?
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2021630
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46,78955,330(8,541)(15.4)%278,798328,263(49,465)(15.1)%489,324348,554140,77040.4%768,122676,81791,30513.5%
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20226302,6902021630
4902022630
2021630
2022630
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202220216301231
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2022202163012313229,217257,977361,7253,210613,1371,1101276103
234,355262,400
202263020211231
202220216301231
124,565139,966151,321213,92255,36671,56023,52545,66171,51259,63927,89427,307454,183558,05520211231558.118.6%2022630454.22022630
202263020211231
202220216301231
4,535,4094,382,8871,172,5542,241,962565,936629,678(BMS)
20226301020216304.138
202263060
20179
2022630
20211
6.5
202112
TIGIT2022
20222021630
20222021
4,382,8871,390,005 (616,522)(295,171) 869,103543,544 (28,847)143,050 (71,212)5,257 152,522396,680
4,535,4091,786,685
20226306.165
102.1841.708
Leap
20216302.952
4.1381,760
1.363
20226308.691
111,1509,5407,50020216305.435
20148,090850750
20226302,880
1.1546,760
1,900
20216301.431
1.126
3,5601,080
1,600
2022630
7,120
20205
2022630
71,36414,28257,082109,70051,35858,342565,936380,729185,20740,90913,89627,013698,687254,109444,57812,7504,2508,50025,1735,74319,430
7,4841,5365,948308,141308,141–1,840,1441,034,044806,100
20226301.097
6,500BMS4,470BMS
3.8071.852
12.5
20226306.987
1,50020226301,280
20216
20226302,520
2022630
20226303.081
427,5202022429
2022630202112314544430720
1222
2022
1002022630660660
2022630202112311.723
4.831
2005
2022630202112315.1%
2.3%2022630
1.177
1994(PBOC)
2022630
2022630
2021123110.1%10.7%
2022630
2022630
2022630
2022630
20226308,600202112318,000
2022630662.22021630445.1
20226304.3202112317.220226
132.120211231145.8
202263020211231
202263020216
C.2.1
Ranjeev Krishana
3.21
D.3.3D.3.7
Thomas MalleyCorazon (Corsee)D. SandersAnthony C. HooperThomasMalley3.10(2)3.21
3.25
E.1.2
Ranjeev Krishana2022622
B.3.1
Donald W. GlazerMichael GollerAlessandro RivaAnthonyC. HooperDonald W. Glazer
B.8
13.51(B)(1)
13.51(B)(1)
2022131
Margaret Han Dugan202221
2022225
Alessandro Riva202221
2022622
202012
174.8515,895,001206,635,013
20.5%2,779,241,000(a)2019103030
36%(b)1.007.842019103126%(c)
2019103126%
201911292022630
20211231
2022
2022
(%)(a)
2,779,241100%1,869,6431,984,939794,302(a)
12.5
20191129
202520191112019129202013
2020924
20.6%
20.4%75,000,000
2020121(a)20%(b)60(c)
202031820209252020109
20219165,5292,151,87750,000,000202263050,000,000
2020720207152020
202,995,338202071214.2308
185145,838,979
20.8
(a)
(b)(c)
(d)20207132020716202263019.21.5
20211215
20216162021
192.60
234.89391.68115,055,260
3,392,616,000
(i)(ii)(iii)(iv)
(v)
202011162021129202142020215142021612021621202162820216302021792021728202110152021
11162021112320211124202111292021113020211222021126202112720211213202112212021122820224292021
202263047169
2022630
20211231
2022
2022
13,245,940–3,309,5499,936,391467,700–348,120119,580150,000–91,09258,908136,360–62,20774,1536,000,000–913,7985,086,2021,630,155––1,630,15521,630,155–4,724,76616,905,389
Thomas MalleyAnthony C. HooperCorazon (Corsee) D. SandersThomas Malley
Corazon (Corsee) D. SandersAnthony C. HooperThomas Malley
2022630
2022630
(www.hkexnews.hk)(www.beigene.com)2022630
2022826
Anthony C. HooperMargaret Han DuganDonald W. GlazerMichael GollerRanjeev KrishanaThomasMalleyAlessandro RivaCorazon (Corsee) D. Sanders